Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model
Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model
There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.
Compartment model, Computational fluid dynamics, High-shear wet granulation, Population-balance model
Abrahamsson, P.J.
5c71c631-5be2-4c5e-bd33-d1666efe995f
Kvist, P.
22bad1e7-7186-4650-a568-11ee8ad1c852
Reynolds, G.
a15b46ea-24f4-452d-8ba4-d48624e3e3b2
Yu, Xi
7e4f553f-cc11-4c6e-ad6d-9fb5c3c07a60
Niklasson Björn, I.
fc714aae-6fd3-4b0b-86a3-de084f807694
Hounslow, M.J.
f883426e-2100-45c5-890b-3d6e8e3a6e68
Rasmuson, A.
5e590675-86e3-4327-a3a8-033d2e1877e0
22 December 2017
Abrahamsson, P.J.
5c71c631-5be2-4c5e-bd33-d1666efe995f
Kvist, P.
22bad1e7-7186-4650-a568-11ee8ad1c852
Reynolds, G.
a15b46ea-24f4-452d-8ba4-d48624e3e3b2
Yu, Xi
7e4f553f-cc11-4c6e-ad6d-9fb5c3c07a60
Niklasson Björn, I.
fc714aae-6fd3-4b0b-86a3-de084f807694
Hounslow, M.J.
f883426e-2100-45c5-890b-3d6e8e3a6e68
Rasmuson, A.
5e590675-86e3-4327-a3a8-033d2e1877e0
Abrahamsson, P.J., Kvist, P., Reynolds, G., Yu, Xi, Niklasson Björn, I., Hounslow, M.J. and Rasmuson, A.
(2017)
Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model.
Particuology, 36.
(doi:10.1016/j.partic.2017.01.008).
Abstract
There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.
Text
Anslysis of meso-scale effects in high shear granulation through a CFD-PBM coupled compartment model-accpeted version
- Accepted Manuscript
More information
Accepted/In Press date: 10 January 2017
e-pub ahead of print date: 20 June 2017
Published date: 22 December 2017
Additional Information:
Publisher Copyright:
© 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
Keywords:
Compartment model, Computational fluid dynamics, High-shear wet granulation, Population-balance model
Identifiers
Local EPrints ID: 482908
URI: http://eprints.soton.ac.uk/id/eprint/482908
ISSN: 1674-2001
PURE UUID: bdacf375-446c-41f0-8e8a-79b9017e67cd
Catalogue record
Date deposited: 17 Oct 2023 16:37
Last modified: 18 Mar 2024 04:14
Export record
Altmetrics
Contributors
Author:
P.J. Abrahamsson
Author:
P. Kvist
Author:
G. Reynolds
Author:
Xi Yu
Author:
I. Niklasson Björn
Author:
M.J. Hounslow
Author:
A. Rasmuson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics