An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis
An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis
FRAX®, a simple-to-use fracture risk calculator, was first released in 2008 and since then has been used increasingly worldwide. By calculating the 10-year probabilities of a major osteoporotic fracture and hip fracture, it assists clinicians when deciding whether further investigation, for example a bone mineral density measurement (BMD), and/or treatment is needed to prevent future fractures. In this review, we explore the literature around osteoporosis and how FRAX has changed its management. We present the characteristics of this tool and describe the use of thresholds (diagnostic and therapeutic). We also present arguments as to why screening with FRAX should be considered. FRAX has several limitations which are described in this review. This review coincides with the release of a version, FRAXplus, which addresses some of these limitations.
Calculator, Epidemiology, FRAX, Fracture risk, Fractures, Osteoporosis
Schini, M.
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Johansson, H.
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Harvey, N.C.
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Lorentzon, M.
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Kanis, J.A.
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McCloskey, E.V.
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Schini, M.
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Johansson, H.
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Harvey, N.C.
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Lorentzon, M.
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Kanis, J.A.
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McCloskey, E.V.
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Schini, M., Johansson, H., Harvey, N.C., Lorentzon, M., Kanis, J.A. and McCloskey, E.V.
(2023)
An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis.
Journal of Endocrinological Investigation.
(doi:10.1007/s40618-023-02219-9).
Abstract
FRAX®, a simple-to-use fracture risk calculator, was first released in 2008 and since then has been used increasingly worldwide. By calculating the 10-year probabilities of a major osteoporotic fracture and hip fracture, it assists clinicians when deciding whether further investigation, for example a bone mineral density measurement (BMD), and/or treatment is needed to prevent future fractures. In this review, we explore the literature around osteoporosis and how FRAX has changed its management. We present the characteristics of this tool and describe the use of thresholds (diagnostic and therapeutic). We also present arguments as to why screening with FRAX should be considered. FRAX has several limitations which are described in this review. This review coincides with the release of a version, FRAXplus, which addresses some of these limitations.
Text
s40618-023-02219-9
- Version of Record
More information
Accepted/In Press date: 3 October 2023
e-pub ahead of print date: 24 October 2023
Additional Information:
Publisher Copyright:
© 2023, The Author(s).
Keywords:
Calculator, Epidemiology, FRAX, Fracture risk, Fractures, Osteoporosis
Identifiers
Local EPrints ID: 483265
URI: http://eprints.soton.ac.uk/id/eprint/483265
ISSN: 1720-8386
PURE UUID: e0ef6ca9-6f41-4559-971e-de3ffd162654
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Date deposited: 27 Oct 2023 16:31
Last modified: 18 Mar 2024 02:59
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Contributors
Author:
M. Schini
Author:
H. Johansson
Author:
M. Lorentzon
Author:
J.A. Kanis
Author:
E.V. McCloskey
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