Association between subclinical atherosclerosis and cardiac structure and function-results from the UK Biobank Study
Association between subclinical atherosclerosis and cardiac structure and function-results from the UK Biobank Study
AIMS: heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease.
METHODS AND RESULTS: participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05).
CONCLUSION: increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes.
Simon, Judit
a7b9d815-c24c-4089-8b7e-fac287eeb9e6
Fung, Kenneth
6cd0db65-96ea-45dd-8d9d-5a7d4f9dbb0a
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Aung, Nay
709b152d-e704-4fdc-b066-7eafaa643a0b
Khanji, Mohammed Y.
fcc9f8c6-b352-4870-8fe0-9ab6676cff86
Zsarnóczay, Emese
e46358d3-0f89-420c-9922-2a527a9a9544
Merkely, Béla
d29a374a-aca8-4ec5-b430-c7c57e68404b
Munroe, Patricia B.
44d23746-20cd-4572-860e-7350424cc031
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Piechnik, Stefan K.
7de3d548-ca5a-40cb-a52b-c53d2dd2278a
Neubauer, Stefan
c8a34156-a4ed-4dfe-97cb-4f47627d927d
Leeson, Paul
34dc217d-32e6-4c63-bcbb-334844939c92
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Maurovich-Horvat, Pál
61249a55-15dd-45aa-a774-a47c029bda4f
Simon, Judit
a7b9d815-c24c-4089-8b7e-fac287eeb9e6
Fung, Kenneth
6cd0db65-96ea-45dd-8d9d-5a7d4f9dbb0a
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Aung, Nay
709b152d-e704-4fdc-b066-7eafaa643a0b
Khanji, Mohammed Y.
fcc9f8c6-b352-4870-8fe0-9ab6676cff86
Zsarnóczay, Emese
e46358d3-0f89-420c-9922-2a527a9a9544
Merkely, Béla
d29a374a-aca8-4ec5-b430-c7c57e68404b
Munroe, Patricia B.
44d23746-20cd-4572-860e-7350424cc031
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Piechnik, Stefan K.
7de3d548-ca5a-40cb-a52b-c53d2dd2278a
Neubauer, Stefan
c8a34156-a4ed-4dfe-97cb-4f47627d927d
Leeson, Paul
34dc217d-32e6-4c63-bcbb-334844939c92
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Maurovich-Horvat, Pál
61249a55-15dd-45aa-a774-a47c029bda4f
Simon, Judit, Fung, Kenneth, Raisi-Estabragh, Zahra, Aung, Nay, Khanji, Mohammed Y., Zsarnóczay, Emese, Merkely, Béla, Munroe, Patricia B., Harvey, Nicholas C., Piechnik, Stefan K., Neubauer, Stefan, Leeson, Paul, Petersen, Steffen E. and Maurovich-Horvat, Pál
(2023)
Association between subclinical atherosclerosis and cardiac structure and function-results from the UK Biobank Study.
European heart journal. Imaging methods and practice, 1 (2), [qyad010].
(doi:10.1093/ehjimp/qyad010).
Abstract
AIMS: heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease.
METHODS AND RESULTS: participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass index, body surface area, hypertension, diabetes, smoking, ethnicity, socioeconomic status, alcohol intake, and laboratory parameters. In total, 4301 individuals (61.6 ± 7.5 years, 45.9% male) were included. Multivariable linear regression analyses showed that increasing quartiles of IMT was associated with increased left and right ventricular (LV and RV) and left atrial volumes and greater LV mass. Moreover, increased IMT was related to lower LV end-systolic circumferential strain, torsion, and both left and right atrial ejection fractions (all P < 0.05).
CONCLUSION: increased IMT showed an independent association over traditional risk factors with enlargement of all four cardiac chambers, decreased function in both atria, greater LV mass, and subclinical LV dysfunction. There may be additional risk stratification that can be derived from the IMT to identify those most likely to have early cardiac structural/functional changes.
Text
qyad010
- Version of Record
More information
Accepted/In Press date: 3 July 2023
e-pub ahead of print date: 19 September 2023
Identifiers
Local EPrints ID: 483267
URI: http://eprints.soton.ac.uk/id/eprint/483267
ISSN: 2755-9637
PURE UUID: 7d701ed9-8b29-4f21-aa24-83234d90f668
Catalogue record
Date deposited: 27 Oct 2023 16:31
Last modified: 18 Mar 2024 02:59
Export record
Altmetrics
Contributors
Author:
Judit Simon
Author:
Kenneth Fung
Author:
Zahra Raisi-Estabragh
Author:
Nay Aung
Author:
Mohammed Y. Khanji
Author:
Emese Zsarnóczay
Author:
Béla Merkely
Author:
Patricia B. Munroe
Author:
Stefan K. Piechnik
Author:
Stefan Neubauer
Author:
Paul Leeson
Author:
Steffen E. Petersen
Author:
Pál Maurovich-Horvat
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
