The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear. The inflammatory adipose microenvironment is central to breast cancer progression and has been shown to favour breast cancer cell growth and to reduce efficacy of anti-cancer treatments. Thus, it is imperative to further our understanding of the inflammatory microenvironment seen in breast cancer patients with obesity. Three-dimensional (3D) in vitro models offer a key tool in increasing our understanding of such complex interactions within the adipose microenvironment. This review discusses some of the approaches utilised to recapitulate the breast tumour microenvironment, including various co-culture and 3D in vitro models. We consider how these model systems contribute to the understanding of breast cancer research, with particular focus on the inflammatory tumour microenvironment. This review aims to provide insight and prospective future directions on the utility of such model systems for breast cancer research.
Humans, Female, Breast Neoplasms/etiology, Breast, Obesity/complications, Adiposity, Risk Factors, Tumor Microenvironment
Blyth, Rhianna Rachael Romany
6dfa48c4-7cb9-405a-ba77-44de4abb424b
Birts, Charlie N.
8689ddad-ba47-4ca6-82c5-001315dbd250
Beers, Stephen A.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
11 September 2023
Blyth, Rhianna Rachael Romany
6dfa48c4-7cb9-405a-ba77-44de4abb424b
Birts, Charlie N.
8689ddad-ba47-4ca6-82c5-001315dbd250
Beers, Stephen A.
a02548be-3ffd-41ab-9db8-d6e8c3b499a2
Blyth, Rhianna Rachael Romany, Birts, Charlie N. and Beers, Stephen A.
(2023)
The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer.
Breast Cancer Research, 25 (1), [104].
(doi:10.1186/s13058-023-01700-w).
Abstract
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity contributes to breast cancer remains unclear. The inflammatory adipose microenvironment is central to breast cancer progression and has been shown to favour breast cancer cell growth and to reduce efficacy of anti-cancer treatments. Thus, it is imperative to further our understanding of the inflammatory microenvironment seen in breast cancer patients with obesity. Three-dimensional (3D) in vitro models offer a key tool in increasing our understanding of such complex interactions within the adipose microenvironment. This review discusses some of the approaches utilised to recapitulate the breast tumour microenvironment, including various co-culture and 3D in vitro models. We consider how these model systems contribute to the understanding of breast cancer research, with particular focus on the inflammatory tumour microenvironment. This review aims to provide insight and prospective future directions on the utility of such model systems for breast cancer research.
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s13058-023-01700-w
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More information
Accepted/In Press date: 16 August 2023
e-pub ahead of print date: 11 September 2023
Published date: 11 September 2023
Additional Information:
Funding Information:
We would like to thank members of the Antibody & Vaccine Group in Southampton, UK, for many helpful discussions in preparing this manuscript.
Funding Information:
RRRB and SAB receive funding from Cancer Research UK. CNB is supported by the Against Breast Cancer Lectureship. CNB and SAB gratefully acknowledge a programme grant from Against Breast Cancer ( www.againstbreastcancer.org.uk ; UK Charity 1121258).
Keywords:
Humans, Female, Breast Neoplasms/etiology, Breast, Obesity/complications, Adiposity, Risk Factors, Tumor Microenvironment
Identifiers
Local EPrints ID: 483274
URI: http://eprints.soton.ac.uk/id/eprint/483274
ISSN: 1465-5411
PURE UUID: 80b29b66-189e-45ae-bde9-01682a49050f
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Date deposited: 27 Oct 2023 16:32
Last modified: 18 Mar 2024 02:56
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Author:
Rhianna Rachael Romany Blyth
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