Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study
Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study
Objective: we examined associations between fat free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan.
Design: prospective, observational study nested within the larger Multi-Center Body Composition Reference Study. FFM, FM, and fat% were estimated using measured deuterium dilution method. Neurodevelopmental outcomes were assessed at 24 months on the INTER-NDA (INTERGROWTH-21st Project Neurodevelopment Assessment) (n = 132).
Results: children with gross motor delays had significantly lower FFM at 18 months (8.01 ± 0.97 kg vs. 7.55 ± 0.20 kg). Children with positive and negative behavior problems had significantly higher fat% at 24 months (20.62 ± 4.30% vs. 18.23 ± 5.46%) and 20.89 ± 4.24% vs. 18.54 ± 5.38%). No associations remained significant after adjusting for covariates. Trajectory modeling showed that between 12 and 18 months, negative behavior scores changed by 13.8 points for every standard deviation change in fat accretion.
Conclusions: our findings highlight the importance of balancing neurodevelopment and metabolic risk when designing nutritional interventions for young children.
Ariff, Shabina
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Aamir, Almas
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Young, Aneurin
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Sikanderali, Laila
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Rizvi, Arjumand
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Shaheen, Fariha
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Khan, Gul Nawaz
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Soofi, Sajid
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Fernandes, Michelle
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Ariff, Shabina
acb1ad6d-2073-47c4-a19b-ee98b1d4773d
Aamir, Almas
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Young, Aneurin
457b536d-6015-4855-8e4c-0a665a9a2bb1
Sikanderali, Laila
f15a9bec-f8f7-4b04-8cd1-784349e026cf
Rizvi, Arjumand
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Shaheen, Fariha
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Khan, Gul Nawaz
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Soofi, Sajid
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Fernandes, Michelle
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Ariff, Shabina, Aamir, Almas, Young, Aneurin, Sikanderali, Laila, Rizvi, Arjumand, Shaheen, Fariha, Khan, Gul Nawaz, Soofi, Sajid and Fernandes, Michelle
(2023)
Differential associations between body composition indices and neurodevelopment during early life in term-born infants: findings from the Pakistan cohort: Multi-Center Body Composition Reference Study.
European Journal of Clinical Nutrition.
(doi:10.1038/s41430-023-01296-6).
Abstract
Objective: we examined associations between fat free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan.
Design: prospective, observational study nested within the larger Multi-Center Body Composition Reference Study. FFM, FM, and fat% were estimated using measured deuterium dilution method. Neurodevelopmental outcomes were assessed at 24 months on the INTER-NDA (INTERGROWTH-21st Project Neurodevelopment Assessment) (n = 132).
Results: children with gross motor delays had significantly lower FFM at 18 months (8.01 ± 0.97 kg vs. 7.55 ± 0.20 kg). Children with positive and negative behavior problems had significantly higher fat% at 24 months (20.62 ± 4.30% vs. 18.23 ± 5.46%) and 20.89 ± 4.24% vs. 18.54 ± 5.38%). No associations remained significant after adjusting for covariates. Trajectory modeling showed that between 12 and 18 months, negative behavior scores changed by 13.8 points for every standard deviation change in fat accretion.
Conclusions: our findings highlight the importance of balancing neurodevelopment and metabolic risk when designing nutritional interventions for young children.
Text
s41430-023-01296-6
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Accepted/In Press date: 31 May 2023
e-pub ahead of print date: 12 July 2023
Additional Information:
Funding Information:
This study was funded by International Atomic Energy Agency, Vienna, Austria (SA, IAEA Doctoral Contract No: 18124/R2). The funding body had no role in the design, analysis or writing of this article.
Funding Information:
We are grateful to the families and participants who have contributed to the study. This study was funded by the International Atomic Energy Agency, Vienna, Austria. The authors are grateful to Alexia J. Alford, Nutrition Specialist at the IAEA, for facilitating the analysis of body composition. MF is supported by a Clinical Research Training Fellowship from the Medical Research Council, UK.
Publisher Copyright:
© 2023, The Author(s).
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Local EPrints ID: 483410
URI: http://eprints.soton.ac.uk/id/eprint/483410
ISSN: 0954-3007
PURE UUID: cdbee31d-9482-4c61-ab25-59c5fc8e0e1b
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Date deposited: 30 Oct 2023 17:45
Last modified: 18 Mar 2024 04:17
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Contributors
Author:
Shabina Ariff
Author:
Almas Aamir
Author:
Aneurin Young
Author:
Laila Sikanderali
Author:
Arjumand Rizvi
Author:
Fariha Shaheen
Author:
Gul Nawaz Khan
Author:
Sajid Soofi
Author:
Michelle Fernandes
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