3D printing of personalised carvedilol tablets using selective laser sintering
3D printing of personalised carvedilol tablets using selective laser sintering
Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.
3D printing, carvedilol, oral, personalised medicines, selective laser sintering
Tabriz, Atabak Ghanizadeh
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Gonot-Munck, Quentin
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Baudoux, Arnaud
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Garg, Vivek
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Farnish, Richard
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Katsamenis, Orestis L.
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Hui, Ho Wah
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Boersen, Nathan
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Roberts, Sandra
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Jones, John
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Douroumis, Dennis
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Tabriz, Atabak Ghanizadeh
fde0d278-7221-44f2-baf2-79e691a54bbf
Gonot-Munck, Quentin
296c2ac1-aeb0-4abf-9e7c-92ee61eef2ad
Baudoux, Arnaud
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Garg, Vivek
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Farnish, Richard
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Katsamenis, Orestis L.
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Hui, Ho Wah
950f5c68-d410-421c-ad12-60602b58f0f1
Boersen, Nathan
a6c5d640-1b5c-41d9-b626-7677a4c7570c
Roberts, Sandra
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Jones, John
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Douroumis, Dennis
daf9057c-2daa-47a7-b5b5-6b92b00346c1
Tabriz, Atabak Ghanizadeh, Gonot-Munck, Quentin, Baudoux, Arnaud, Garg, Vivek, Farnish, Richard, Katsamenis, Orestis L., Hui, Ho Wah, Boersen, Nathan, Roberts, Sandra, Jones, John and Douroumis, Dennis
(2023)
3D printing of personalised carvedilol tablets using selective laser sintering.
Pharmaceutics, 15 (9), [2230].
(doi:10.3390/pharmaceutics15092230).
Abstract
Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO2 laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO2 intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.
Text
pharmaceutics-15-02230
- Version of Record
More information
Accepted/In Press date: 23 August 2023
e-pub ahead of print date: 29 August 2023
Additional Information:
Funding Information:
Beamtime allocation at the μ-VIS X-ray Imaging Centre/3D X-ray Histology facility (www.muvis.org/www.xrayhistology.org) was supported by the National Research Facility for Lab-based X-ray CT (nxct.ac.uk) through EPSRC grant EP/T02593X/1. The authors acknowledge NVIDIA corporation for providing a NVIDIA RTX A6000 used for the μ-CT visualisation and analysis.
Keywords:
3D printing, carvedilol, oral, personalised medicines, selective laser sintering
Identifiers
Local EPrints ID: 483489
URI: http://eprints.soton.ac.uk/id/eprint/483489
ISSN: 1999-4923
PURE UUID: 5bb23c95-2232-4c41-863c-60a90ec34c19
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Date deposited: 31 Oct 2023 18:18
Last modified: 18 Mar 2024 03:18
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Contributors
Author:
Atabak Ghanizadeh Tabriz
Author:
Quentin Gonot-Munck
Author:
Arnaud Baudoux
Author:
Vivek Garg
Author:
Richard Farnish
Author:
Ho Wah Hui
Author:
Nathan Boersen
Author:
Sandra Roberts
Author:
John Jones
Author:
Dennis Douroumis
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