Chinese herb Patrinia Herba (Bai Jiang Cao) for acute respiratory tract infections: a systematic review of clinical studies
Chinese herb Patrinia Herba (Bai Jiang Cao) for acute respiratory tract infections: a systematic review of clinical studies
Introduction: acute respiratory tract infections (ARTIs) are a group of common diseases with a high incidence that cause tremendous pressure on the healthcare system globally. Patrinia Herba (Bai Jiang Cao) has a long history of use in China. This systematic review aimed to evaluate the clinical effectiveness and safety of Patrinia Herba for ARTIs.
Methods: we searched the Chinese and English databases from their inception to March 2022 for clinical studies that tested single-herb preparations or formulae containing Patrinia Herba for ARTIs. We used the Cochrane Risk of Bias 2 and non-randomised studies as intervention tools for quality assessment. The review protocol was registered with PROSPERO (CRD42021260330).
Results: six trials (2 107 participants) were identified. Two trials were pooled. The results showed that, in adults and children with influenza, single Patrinia Herba granules or injections improved the participants’ feelings of aversion to cold, general malaise, nasal obstruction, runny nose, sore throat, cough, headache, and dizziness after a two-day treatment. For adults and children with pneumonia, Patrinia Herba compound preparations plus antibiotics appeared better than antibiotics alone in relieving fever, cough, shortness of breath, and chest pain. The overall methodological quality of the included randomised controlled trials was rated as unclear, low, or moderate for controlled clinical trials. No severe adverse events were reported.
Discussion: low- or moderate-quality evidence demonstrates that single herb or compound preparations of Patrinia Herba may be effective for ARTIs in terms of symptom remission. Further high-quality studies are needed to confirm their potential for treating ARTIs.
Acute respiratory tract infections, Chinese herb, Clinical trials, Patrinia Herba, Systematic review
Zheng, R.-X.
293edce2-2f8a-46c7-ae64-a1f41ccfd162
Yu, Z.-Y.
2be4cf3a-f53e-46f6-a867-575158379233
Shen, C.
b42f0da4-491a-46bc-9362-f84a80119b89
Willcox, M.
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Trill, J.
65ee5141-abbb-4389-9bd1-5da6199a26cb
Moore, M.
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Hu, X.-Y.
65904b24-3775-4b14-9532-eb703a056655
Liu, J.-P.
f55efaf5-c3a1-4b63-9063-6aede27ad971
26 October 2023
Zheng, R.-X.
293edce2-2f8a-46c7-ae64-a1f41ccfd162
Yu, Z.-Y.
2be4cf3a-f53e-46f6-a867-575158379233
Shen, C.
b42f0da4-491a-46bc-9362-f84a80119b89
Willcox, M.
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Trill, J.
65ee5141-abbb-4389-9bd1-5da6199a26cb
Moore, M.
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Hu, X.-Y.
65904b24-3775-4b14-9532-eb703a056655
Liu, J.-P.
f55efaf5-c3a1-4b63-9063-6aede27ad971
Zheng, R.-X., Yu, Z.-Y., Shen, C., Willcox, M., Trill, J., Moore, M., Hu, X.-Y. and Liu, J.-P.
(2023)
Chinese herb Patrinia Herba (Bai Jiang Cao) for acute respiratory tract infections: a systematic review of clinical studies.
Journal of Herbal Medicine, 42, [100791].
(doi:10.1016/j.hermed.2023.100791).
Abstract
Introduction: acute respiratory tract infections (ARTIs) are a group of common diseases with a high incidence that cause tremendous pressure on the healthcare system globally. Patrinia Herba (Bai Jiang Cao) has a long history of use in China. This systematic review aimed to evaluate the clinical effectiveness and safety of Patrinia Herba for ARTIs.
Methods: we searched the Chinese and English databases from their inception to March 2022 for clinical studies that tested single-herb preparations or formulae containing Patrinia Herba for ARTIs. We used the Cochrane Risk of Bias 2 and non-randomised studies as intervention tools for quality assessment. The review protocol was registered with PROSPERO (CRD42021260330).
Results: six trials (2 107 participants) were identified. Two trials were pooled. The results showed that, in adults and children with influenza, single Patrinia Herba granules or injections improved the participants’ feelings of aversion to cold, general malaise, nasal obstruction, runny nose, sore throat, cough, headache, and dizziness after a two-day treatment. For adults and children with pneumonia, Patrinia Herba compound preparations plus antibiotics appeared better than antibiotics alone in relieving fever, cough, shortness of breath, and chest pain. The overall methodological quality of the included randomised controlled trials was rated as unclear, low, or moderate for controlled clinical trials. No severe adverse events were reported.
Discussion: low- or moderate-quality evidence demonstrates that single herb or compound preparations of Patrinia Herba may be effective for ARTIs in terms of symptom remission. Further high-quality studies are needed to confirm their potential for treating ARTIs.
Text
1-s2.0-S2210803323001690-main
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More information
Accepted/In Press date: 29 September 2023
e-pub ahead of print date: 1 October 2023
Published date: 26 October 2023
Additional Information:
Funding Information:
This review was funded by the National Key Research and Development Project (grant no. 2018YFE0102300) in China and by Innovate UK (grant no. 104287–610239).
Keywords:
Acute respiratory tract infections, Chinese herb, Clinical trials, Patrinia Herba, Systematic review
Identifiers
Local EPrints ID: 483800
URI: http://eprints.soton.ac.uk/id/eprint/483800
ISSN: 2210-8033
PURE UUID: ebad87a3-0b71-4b3d-9fa3-b8735370c68d
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Date deposited: 06 Nov 2023 18:00
Last modified: 18 Mar 2024 03:39
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Contributors
Author:
R.-X. Zheng
Author:
Z.-Y. Yu
Author:
C. Shen
Author:
J. Trill
Author:
J.-P. Liu
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