Measurement of visual function in infantile nystagmus: a systematic review
Measurement of visual function in infantile nystagmus: a systematic review
Background/aims: Recent work has called into question the ability of visual acuity (VA) to accurately represent changes in visual function in infantile nystagmus (IN). This systematic review investigated factors affecting visual performance in IN, to guide development of suitable alternatives to VA. Methods: Included studies used an experimental manipulation to assess changes in visual function in people with IN. Interventional studies, case series and case studies were excluded. Six databases were searched in August 2023. Selection, detection, attrition and measurement bias were assessed. Due to heterogeneous methodologies, narrative synthesis was undertaken. Results: Eighteen relevant papers were identified, 11 of which complied with the review criteria. Articles were grouped according to the factor manipulated to evoke within-participant changes in performance (motion blur, psychological state, gaze angle or visual crowding). Optotype, image, grating and moving stimuli have been employed under varying lighting conditions and exposure duration. Conclusion: Several factors affecting visual performance should be considered when assessing visual function in IN. While maximum VA is a useful metric, its measurement deliberately minimises nystagmus-specific factors such as changes in visual performance with gaze angle and the € slow to see' phenomenon. Maximum VA can be measured using the null zone, providing unlimited viewing time, reducing stress/mental load and minimising visual crowding. Gaze-dependent functional vision space is a promising measure which quantifies the impact of the null zone but does not consider temporal vision. Although no complete measurement technique has yet been proven, this review provides insights to guide future work towards development of appropriate methods.
diagnostic tests/investigation, psychophysics, vision, visual perception
Almagren, Bader A.
584612e1-b1c9-47f9-ade6-6d34c8539648
Dunn, Matt J.
fab9d2ea-2428-4c2d-8c72-7c07515b7dfc
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389
Lee, Helena
5d36fd1e-9334-4db5-b201-034d147133fb
Almagren, Bader A.
584612e1-b1c9-47f9-ade6-6d34c8539648
Dunn, Matt J.
fab9d2ea-2428-4c2d-8c72-7c07515b7dfc
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389
Lee, Helena
5d36fd1e-9334-4db5-b201-034d147133fb
Almagren, Bader A. and Dunn, Matt J.
,
NUKE
(2023)
Measurement of visual function in infantile nystagmus: a systematic review.
British Journal of Ophthalmology, [bjo-2023-324254].
(doi:10.1136/bjo-2023-324254).
Abstract
Background/aims: Recent work has called into question the ability of visual acuity (VA) to accurately represent changes in visual function in infantile nystagmus (IN). This systematic review investigated factors affecting visual performance in IN, to guide development of suitable alternatives to VA. Methods: Included studies used an experimental manipulation to assess changes in visual function in people with IN. Interventional studies, case series and case studies were excluded. Six databases were searched in August 2023. Selection, detection, attrition and measurement bias were assessed. Due to heterogeneous methodologies, narrative synthesis was undertaken. Results: Eighteen relevant papers were identified, 11 of which complied with the review criteria. Articles were grouped according to the factor manipulated to evoke within-participant changes in performance (motion blur, psychological state, gaze angle or visual crowding). Optotype, image, grating and moving stimuli have been employed under varying lighting conditions and exposure duration. Conclusion: Several factors affecting visual performance should be considered when assessing visual function in IN. While maximum VA is a useful metric, its measurement deliberately minimises nystagmus-specific factors such as changes in visual performance with gaze angle and the € slow to see' phenomenon. Maximum VA can be measured using the null zone, providing unlimited viewing time, reducing stress/mental load and minimising visual crowding. Gaze-dependent functional vision space is a promising measure which quantifies the impact of the null zone but does not consider temporal vision. Although no complete measurement technique has yet been proven, this review provides insights to guide future work towards development of appropriate methods.
Text
Paper_MeasurementOfVisualFunctionInInfantileNystagmus_PostPrint[24]
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Accepted/In Press date: 30 October 2023
e-pub ahead of print date: 6 December 2023
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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords:
diagnostic tests/investigation, psychophysics, vision, visual perception
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Local EPrints ID: 483896
URI: http://eprints.soton.ac.uk/id/eprint/483896
ISSN: 0007-1161
PURE UUID: 33938619-12b7-4b5c-b235-a4c896c312bb
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Date deposited: 07 Nov 2023 18:07
Last modified: 18 Mar 2024 03:32
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Contributors
Author:
Bader A. Almagren
Author:
Matt J. Dunn
Corporate Author: NUKE
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