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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

Animals, Communicable Diseases, Emerging/epidemiology, Cystic Fibrosis/epidemiology, Drug Resistance, Multiple, Bacterial, Genome, Bacterial, Genomics, Humans, Incidence, Lung/microbiology, Mice, Mice, SCID, Mycobacterium Infections, Nontuberculous/epidemiology, Nontuberculous Mycobacteria/classification, Phylogeny, Pneumonia, Bacterial/epidemiology, Polymorphism, Single Nucleotide, Sequence Analysis, DNA
0036-8075
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Bryant, Josephine M, Grogono, Dorothy M, Rodriguez-Rincon, Daniela, Everall, Isobel, Brown, Karen P, Moreno, Pablo, Verma, Deepshikha, Hill, Emily, Drijkoningen, Judith, Gilligan, Peter, Esther, Charles R, Noone, Peadar G, Giddings, Olivia, Bell, Scott C, Thomson, Rachel, Wainwright, Claire E, Coulter, Chris, Pandey, Sushil, Wood, Michelle E, Stockwell, Rebecca E, Ramsay, Kay A, Sherrard, Laura J, Kidd, Timothy J, Jabbour, Nassib, Johnson, Graham R, Knibbs, Luke D, Morawska, Lidia, Sly, Peter D, Jones, Andrew, Bilton, Diana, Laurenson, Ian, Ruddy, Michael, Bourke, Stephen, Bowler, Ian Cjw, Chapman, Stephen J, Clayton, Andrew, Cullen, Mairi, Daniels, Thomas, Dempsey, Owen, Denton, Miles, Desai, Maya, Drew, Richard J, Edenborough, Frank, Evans, Jason, Folb, Jonathan, Humphrey, Helen, Isalska, Barbara, Jensen-Fangel, Søren, Jönsson, Bodil, Jones, Andrew, Katzenstein, Terese L, Lillebaek, Troels, MacGregor, Gordon, Mayell, Sarah, Millar, Michael, Modha, Deborah, Nash, Edward F, O'Brien, Christopher, O'Brien, Deirdre, Ohri, Chandra, Pao, Caroline S, Peckham, Daniel, Perrin, Felicity, Perry, Audrey, Pressler, Tania, Prtak, Laura, Qvist, Tavs, Robb, Ali, Rodgers, Helen, Schaffer, Kirsten, Shafi, Nadia, van Ingen, Jakko, Walshaw, Martin, Watson, Danie, West, Noreen, Whitehouse, Joanna, Haworth, Charles S, Harris, Simon R, Ordway, Diane, Parkhill, Julian and Floto, R Andres (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science (New York, N.Y.), 354 (6313), 751-757. (doi:10.1126/science.aaf8156).

Record type: Article

Abstract

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.

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More information

Published date: 11 November 2016
Additional Information: Copyright © 2016, American Association for the Advancement of Science.
Keywords: Animals, Communicable Diseases, Emerging/epidemiology, Cystic Fibrosis/epidemiology, Drug Resistance, Multiple, Bacterial, Genome, Bacterial, Genomics, Humans, Incidence, Lung/microbiology, Mice, Mice, SCID, Mycobacterium Infections, Nontuberculous/epidemiology, Nontuberculous Mycobacteria/classification, Phylogeny, Pneumonia, Bacterial/epidemiology, Polymorphism, Single Nucleotide, Sequence Analysis, DNA

Identifiers

Local EPrints ID: 483957
URI: http://eprints.soton.ac.uk/id/eprint/483957
DOI: doi:10.1126/science.aaf8156
ISSN: 0036-8075
PURE UUID: ab6eb3de-df41-4f9f-8db8-653a2fa271fc

Catalogue record

Date deposited: 07 Nov 2023 18:53
Last modified: 17 Mar 2024 05:41

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Contributors

Author: Josephine M Bryant
Author: Dorothy M Grogono
Author: Daniela Rodriguez-Rincon
Author: Isobel Everall
Author: Karen P Brown
Author: Pablo Moreno
Author: Deepshikha Verma
Author: Emily Hill
Author: Judith Drijkoningen
Author: Peter Gilligan
Author: Charles R Esther
Author: Peadar G Noone
Author: Olivia Giddings
Author: Scott C Bell
Author: Rachel Thomson
Author: Claire E Wainwright
Author: Chris Coulter
Author: Sushil Pandey
Author: Michelle E Wood
Author: Rebecca E Stockwell
Author: Kay A Ramsay
Author: Laura J Sherrard
Author: Timothy J Kidd
Author: Nassib Jabbour
Author: Graham R Johnson
Author: Luke D Knibbs
Author: Lidia Morawska
Author: Peter D Sly
Author: Andrew Jones
Author: Diana Bilton
Author: Ian Laurenson
Author: Michael Ruddy
Author: Stephen Bourke
Author: Ian Cjw Bowler
Author: Stephen J Chapman
Author: Andrew Clayton
Author: Mairi Cullen
Author: Thomas Daniels
Author: Owen Dempsey
Author: Miles Denton
Author: Maya Desai
Author: Richard J Drew
Author: Frank Edenborough
Author: Jason Evans
Author: Jonathan Folb
Author: Helen Humphrey
Author: Barbara Isalska
Author: Søren Jensen-Fangel
Author: Bodil Jönsson
Author: Andrew Jones
Author: Terese L Katzenstein
Author: Troels Lillebaek
Author: Gordon MacGregor
Author: Sarah Mayell
Author: Michael Millar
Author: Deborah Modha
Author: Edward F Nash
Author: Christopher O'Brien
Author: Deirdre O'Brien
Author: Chandra Ohri
Author: Caroline S Pao
Author: Daniel Peckham
Author: Felicity Perrin
Author: Audrey Perry
Author: Tania Pressler
Author: Laura Prtak
Author: Tavs Qvist
Author: Ali Robb
Author: Helen Rodgers
Author: Kirsten Schaffer
Author: Nadia Shafi
Author: Jakko van Ingen
Author: Martin Walshaw
Author: Danie Watson
Author: Noreen West
Author: Joanna Whitehouse
Author: Charles S Haworth
Author: Simon R Harris
Author: Diane Ordway
Author: Julian Parkhill
Author: R Andres Floto

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