T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this ‘normalises’ CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
1353-1355
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
27 October 2020
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Hanley, Christopher J. and Thomas, Gareth J.
(2020)
T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting.
British Journal of Cancer, 123, .
(doi:10.1038/s41416-020-1020-6).
Abstract
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this ‘normalises’ CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
Text
s41416-020-1020-6
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More information
Accepted/In Press date: 22 July 2020
e-pub ahead of print date: 24 August 2020
Published date: 27 October 2020
Additional Information:
Funding Information: the work described in the commentary was funded through Cancer Research UK (grant nos. A203904, A20256 and A27989) and Medical Research Council UK (grant no. MR/P013414/1).
Identifiers
Local EPrints ID: 484005
URI: http://eprints.soton.ac.uk/id/eprint/484005
ISSN: 0007-0920
PURE UUID: 6bfc2daa-33d2-4e21-9283-5a6c2fb77ac9
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Date deposited: 08 Nov 2023 18:23
Last modified: 18 Mar 2024 03:31
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