Lipid droplets in steatotic liver disease
Lipid droplets in steatotic liver disease
Purpose of review: this review aims to discuss the most recent evidence exploring the role of lipid droplets in steatotic liver disease (SLD). We highlight the breadth of mechanisms by which lipid droplets may contribute to the progression of SLD with a particular focus on the role of lipid droplets as inducers of mechanical stress within hepatocytes and genetic mutations in lipid droplet associated proteins. Finally, this review provides an update on clinical trials exploring the therapeutic potential and strategies targeting lipid droplets.
Recent findings: the size, composition and location of hepatic lipid droplets strongly influence the pathological role of these organelles in SLD. Emerging studies are beginning to elucidate the importance of lipid droplet induced hepatocyte mechanical stress. Novel strategies targeting lipid droplets, including the effects of lipid droplet associated protein mutations, show promising therapeutic potential.
Summary: much more than a histological feature, lipid droplets are complex heterogenous organelles crucial to cellular metabolism with important causative roles in the development and progression of SLD. Lipid droplet induced mechanical stress may exacerbate hepatic inflammation and fibrogenesis and potentially contribute to the development of a pro-carcinogenic hepatic environment. The integration of advancements in genetics and molecular biology in upcoming treatments aspires to transcend symptomatic alleviation and address the fundamental causes and pathological development of SLD.
lipid droplet, steatosis, steatotic liver disease
91-97
Bilson, Josh
a99f9320-335c-47c8-bf30-07df48a5467d
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
1 March 2024
Bilson, Josh
a99f9320-335c-47c8-bf30-07df48a5467d
Scorletti, Eleonora
4e896544-2974-4f81-9696-1595d3c36814
Bilson, Josh and Scorletti, Eleonora
(2024)
Lipid droplets in steatotic liver disease.
Current Opinion in Clinical Nutrition and Metabolic Care, 27 (2), .
(doi:10.1097/MCO.0000000000000993).
Abstract
Purpose of review: this review aims to discuss the most recent evidence exploring the role of lipid droplets in steatotic liver disease (SLD). We highlight the breadth of mechanisms by which lipid droplets may contribute to the progression of SLD with a particular focus on the role of lipid droplets as inducers of mechanical stress within hepatocytes and genetic mutations in lipid droplet associated proteins. Finally, this review provides an update on clinical trials exploring the therapeutic potential and strategies targeting lipid droplets.
Recent findings: the size, composition and location of hepatic lipid droplets strongly influence the pathological role of these organelles in SLD. Emerging studies are beginning to elucidate the importance of lipid droplet induced hepatocyte mechanical stress. Novel strategies targeting lipid droplets, including the effects of lipid droplet associated protein mutations, show promising therapeutic potential.
Summary: much more than a histological feature, lipid droplets are complex heterogenous organelles crucial to cellular metabolism with important causative roles in the development and progression of SLD. Lipid droplet induced mechanical stress may exacerbate hepatic inflammation and fibrogenesis and potentially contribute to the development of a pro-carcinogenic hepatic environment. The integration of advancements in genetics and molecular biology in upcoming treatments aspires to transcend symptomatic alleviation and address the fundamental causes and pathological development of SLD.
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20231108_NAFLD_LipidDroplets (002)
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More information
Accepted/In Press date: 1 November 2023
e-pub ahead of print date: 15 November 2023
Published date: 1 March 2024
Additional Information:
Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
Keywords:
lipid droplet, steatosis, steatotic liver disease
Identifiers
Local EPrints ID: 484214
URI: http://eprints.soton.ac.uk/id/eprint/484214
ISSN: 1363-1950
PURE UUID: 9a81c403-de90-410b-83c2-962b53a65b03
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Date deposited: 13 Nov 2023 18:40
Last modified: 24 Apr 2024 02:08
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Contributors
Author:
Josh Bilson
Author:
Eleonora Scorletti
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