Human leukocyte immunoglobulin-like receptors in health and disease
Human leukocyte immunoglobulin-like receptors in health and disease
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance. Abnormal expression and function of LILRs is associated with a range of pathologies, including immune insufficiency (infection and malignancy) and overt immune responses (autoimmunity and alloresponses), suggesting LILRs may be excellent candidates for targeted immunotherapies. This review will discuss the biology and clinical relevance of this extensive family of immune receptors and will summarise the recent developments in targeting LILRs in disease settings, such as cancer, with an update on the clinical trials investigating the therapeutic targeting of these receptors.
Humans, Immunoglobulins, Immunomodulation, LILR, Leukocytes, Myeloid Cells, Receptors, Immunologic/metabolism, autoimmunity, cancer, immune tolerance, immunomodulation, immunotherapy, infection
Redondo-García, Silvia
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Barritt, Christopher
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Papagregoriou, Charys
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Yeboah, Muchaala
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Frendeus, Björn
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Cragg, Mark S.
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Roghanian, Ali
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2023
Redondo-García, Silvia
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Barritt, Christopher
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Papagregoriou, Charys
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Yeboah, Muchaala
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Frendeus, Björn
50bf6a56-176f-4784-932a-21c10e87805b
Cragg, Mark S.
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Roghanian, Ali
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Redondo-García, Silvia, Barritt, Christopher, Papagregoriou, Charys, Yeboah, Muchaala, Frendeus, Björn, Cragg, Mark S. and Roghanian, Ali
(2023)
Human leukocyte immunoglobulin-like receptors in health and disease.
Frontiers in Immunology, 14, [1282874].
(doi:10.3389/fimmu.2023.1282874).
Abstract
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance. Abnormal expression and function of LILRs is associated with a range of pathologies, including immune insufficiency (infection and malignancy) and overt immune responses (autoimmunity and alloresponses), suggesting LILRs may be excellent candidates for targeted immunotherapies. This review will discuss the biology and clinical relevance of this extensive family of immune receptors and will summarise the recent developments in targeting LILRs in disease settings, such as cancer, with an update on the clinical trials investigating the therapeutic targeting of these receptors.
Text
fimmu-14-1282874
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More information
Accepted/In Press date: 20 September 2023
e-pub ahead of print date: 13 November 2023
Published date: 2023
Additional Information:
Publisher Copyright:
Copyright © 2023 Redondo-García, Barritt, Papagregoriou, Yeboah, Frendeus, Cragg and Roghanian.
Copyright © 2023 Redondo-García, Barritt, Papagregoriou, Yeboah, Frendeus, Cragg and Roghanian.
Keywords:
Humans, Immunoglobulins, Immunomodulation, LILR, Leukocytes, Myeloid Cells, Receptors, Immunologic/metabolism, autoimmunity, cancer, immune tolerance, immunomodulation, immunotherapy, infection
Identifiers
Local EPrints ID: 484317
URI: http://eprints.soton.ac.uk/id/eprint/484317
ISSN: 1664-3224
PURE UUID: ca5a0e90-e14f-4f4d-8675-d5e0b6cab4e3
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Date deposited: 15 Nov 2023 18:00
Last modified: 21 Mar 2024 03:12
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Contributors
Author:
Silvia Redondo-García
Author:
Christopher Barritt
Author:
Charys Papagregoriou
Author:
Muchaala Yeboah
Author:
Björn Frendeus
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