Photoacoustic radiofrequency spectroscopy for monitoring cancer treatment response
Photoacoustic radiofrequency spectroscopy for monitoring cancer treatment response
Frequency analysis of the photoacoustic (PA) signals was combined with functional PA estimations of tumor oxygenation to monitor the in-vivo response of a temperature sensitive liposome treatment. Mouse breast cancer tumors were imaged using the Vevo LAZR system (Fujifilm VisualSonics, Toronto, Canada) before treatment and 30 min/2h/5h/24h/7d post-treatment. Treatment consisted of an injection of either the liposome (HaT-DOX) or saline followed by heating of the tumour in a water bath for 1 hour at 43°C. The tumor oxygenation and the slope of the normalise power spectrum decreased by 22% and 45% at 750 nm, respectively as early as 30 minutes post-treatment. The combined analysis was able to differentiate responding mice from their non-responding counterparts and the control group. These results suggest that probing both structural (spectral slope) and functional (oxygen saturation) changes that occur during cancer treatment can aid in identifying treatment response.
cancer treatment monitoring, oxygen saturation, photoacoustic frequency analysis, quantitative photoacoustics
Hysi, Eno
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Wirtzfeld, Lauren A.
e46c0f07-84dc-4439-b349-36f81c49c413
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Undzys, Elijus
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Li, Shyh Dar
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Kolios, Michael C.
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Hysi, Eno
930da6bf-baf4-4334-8cc8-ee0264476b32
Wirtzfeld, Lauren A.
e46c0f07-84dc-4439-b349-36f81c49c413
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Undzys, Elijus
226e7879-8bef-4715-9e72-d405e59d6dcb
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
Kolios, Michael C.
524bd088-1670-4d3c-9817-5298a4b1eebd
Hysi, Eno, Wirtzfeld, Lauren A., May, Jonathan P., Undzys, Elijus, Li, Shyh Dar and Kolios, Michael C.
(2016)
Photoacoustic radiofrequency spectroscopy for monitoring cancer treatment response.
In 2016 IEEE International Ultrasonics Symposium (IUS).
vol. 2016-November,
IEEE.
4 pp
.
(doi:10.1109/ULTSYM.2016.7728511).
Record type:
Conference or Workshop Item
(Paper)
Abstract
Frequency analysis of the photoacoustic (PA) signals was combined with functional PA estimations of tumor oxygenation to monitor the in-vivo response of a temperature sensitive liposome treatment. Mouse breast cancer tumors were imaged using the Vevo LAZR system (Fujifilm VisualSonics, Toronto, Canada) before treatment and 30 min/2h/5h/24h/7d post-treatment. Treatment consisted of an injection of either the liposome (HaT-DOX) or saline followed by heating of the tumour in a water bath for 1 hour at 43°C. The tumor oxygenation and the slope of the normalise power spectrum decreased by 22% and 45% at 750 nm, respectively as early as 30 minutes post-treatment. The combined analysis was able to differentiate responding mice from their non-responding counterparts and the control group. These results suggest that probing both structural (spectral slope) and functional (oxygen saturation) changes that occur during cancer treatment can aid in identifying treatment response.
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More information
e-pub ahead of print date: 3 November 2016
Venue - Dates:
2016 IEEE International Ultrasonics Symposium, IUS 2016, , Tours, France, 2016-09-18 - 2016-09-21
Keywords:
cancer treatment monitoring, oxygen saturation, photoacoustic frequency analysis, quantitative photoacoustics
Identifiers
Local EPrints ID: 484531
URI: http://eprints.soton.ac.uk/id/eprint/484531
ISSN: 1948-5719
PURE UUID: 3a5681a8-0835-4e3f-9fdb-be2b38e7b19e
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Date deposited: 16 Nov 2023 14:44
Last modified: 17 Mar 2024 03:53
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Contributors
Author:
Eno Hysi
Author:
Lauren A. Wirtzfeld
Author:
Elijus Undzys
Author:
Shyh Dar Li
Author:
Michael C. Kolios
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