Real world outcomes of photodynamic therapy for chronic central serous chorioretinopathy
Real world outcomes of photodynamic therapy for chronic central serous chorioretinopathy
Objectives: We describe the real-world outcomes of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR) in a single centre over nine years. Methods: We carried out a retrospective analysis of patients with chronic CSCR who received half dose PDT in a single centre between 2011 and 2019. Visual acuity (VA) and retinal thickness (RT) was recorded between baseline visit and first recorded review visit. Results: We included 125 eyes of 113 patients in this study. Mean age at treatment was 55.0 ± 12.1 years, with a higher male predominance (83 men, 30 women). Mean baseline VA was 0.40 ± 0.31 logMAR with a mean visual outcome gain post-PDT of 0.05 logMAR (p = 0.005). Mean baseline RT was 390 ± 82 microns with a mean reduction of RT post-PDT of 66 microns (p < 0.001). 17.6% of eyes were treated for recurrent CSCR. Conclusion: We found overall a mean improvement in VA and structural outcomes after PDT. In the absence of randomised clinical trials this study supports the use of half dose PDT for treatment of chronic CSCR.
2548-2553
Khandhadia, Samir
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Thulasidharan, Suresh
e8796b76-d3ad-4bd7-96cb-70c05bf916c6
Hoang, Nguyen Thuy Vy
a27ad807-3d85-48d7-a8b7-d624e1c6e1db
Ibrahim, Sameh Alkhalili
8a089d6d-5b84-4ace-9bdd-e58847c2c3a6
Ouyang, Yanling
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Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
1 August 2023
Khandhadia, Samir
affa5c7c-07a1-4a97-a514-31114472e89e
Thulasidharan, Suresh
e8796b76-d3ad-4bd7-96cb-70c05bf916c6
Hoang, Nguyen Thuy Vy
a27ad807-3d85-48d7-a8b7-d624e1c6e1db
Ibrahim, Sameh Alkhalili
8a089d6d-5b84-4ace-9bdd-e58847c2c3a6
Ouyang, Yanling
d73d6c00-7595-4b59-b240-d1d73e5cb183
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Khandhadia, Samir, Thulasidharan, Suresh, Hoang, Nguyen Thuy Vy, Ibrahim, Sameh Alkhalili, Ouyang, Yanling and Lotery, Andrew
(2023)
Real world outcomes of photodynamic therapy for chronic central serous chorioretinopathy.
Eye, 37 (12), .
(doi:10.1038/s41433-022-02370-2).
Abstract
Objectives: We describe the real-world outcomes of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR) in a single centre over nine years. Methods: We carried out a retrospective analysis of patients with chronic CSCR who received half dose PDT in a single centre between 2011 and 2019. Visual acuity (VA) and retinal thickness (RT) was recorded between baseline visit and first recorded review visit. Results: We included 125 eyes of 113 patients in this study. Mean age at treatment was 55.0 ± 12.1 years, with a higher male predominance (83 men, 30 women). Mean baseline VA was 0.40 ± 0.31 logMAR with a mean visual outcome gain post-PDT of 0.05 logMAR (p = 0.005). Mean baseline RT was 390 ± 82 microns with a mean reduction of RT post-PDT of 66 microns (p < 0.001). 17.6% of eyes were treated for recurrent CSCR. Conclusion: We found overall a mean improvement in VA and structural outcomes after PDT. In the absence of randomised clinical trials this study supports the use of half dose PDT for treatment of chronic CSCR.
Text
s41433-022-02370-2
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Accepted/In Press date: 15 December 2022
e-pub ahead of print date: 26 December 2022
Published date: 1 August 2023
Additional Information:
Funding Information:
We would like to acknowledge Prof Sobha Sivaprasad (Moorfields Hospital, London, UK) for her helpful comments on reviewing this paper. No financial support was received in support of this study
Publisher Copyright:
© 2022, The Author(s).
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Local EPrints ID: 484663
URI: http://eprints.soton.ac.uk/id/eprint/484663
ISSN: 0950-222X
PURE UUID: ef444525-9b12-466f-80e0-faff487a4e17
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Date deposited: 20 Nov 2023 17:35
Last modified: 18 Mar 2024 02:57
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Contributors
Author:
Samir Khandhadia
Author:
Suresh Thulasidharan
Author:
Nguyen Thuy Vy Hoang
Author:
Sameh Alkhalili Ibrahim
Author:
Yanling Ouyang
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