Variability in the reporting of baseline characteristics, treatment, and outcomes in esophageal atresia publications: a systematic review
Variability in the reporting of baseline characteristics, treatment, and outcomes in esophageal atresia publications: a systematic review
Introduction: as survival rates of infants born with esophageal atresia (EA) have improved considerably, research interests are shifting from viability to morbidity and longer-term outcomes. This review aims to identify all parameters studied in recent EA research and determine variability in their reporting, utilization, and definition.
Materials and methods: following PRISMA guidelines, we performed a systematic review of literature regarding the main EA care process, published between 2015 and 2021, combining the search term esophageal atresia with morbidity, mortality, survival, outcome, or complication. Described outcomes were extracted from included publications, along with study and baseline characteristics.
Results: from 209 publications that met the inclusion criteria, 731 studied parameters were extracted and categorized into patient characteristics (n = 128), treatment and care process characteristics (n = 338), and outcomes (n = 265). Ninety-two of these were reported in more than 5% of included publications. Most frequently reported characteristics were sex (85%), EA type (74%), and repair type (60%). Most frequently reported outcomes were anastomotic stricture (72%), anastomotic leakage (68%), and mortality (66%).
Conclusion: this study demonstrates considerable heterogeneity of studied parameters in EA research, emphasizing the need for standardized reporting to compare results of EA research. Additionally, the identified items may help develop an informed, evidence-based consensus on outcome measurement in esophageal atresia research and standardized data collection in registries or clinical audits, thereby enabling benchmarking and comparing care between centers, regions, and countries.
characteristics, esophageal atresia, outcome
129-137
Teunissen, Nadine
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Brendel, Julia
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Eaton, Simon
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Hall, Nigel
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Thursfield, Rebecca
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van Heurn, Ernest L.W.
5532bb9b-634e-47c9-82fe-45625908ae89
Ure, Benno
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Wijnen, Rene
ac0cf8b0-684a-4d1d-a1d2-3513d40d0bf0
1 April 2023
Teunissen, Nadine
2cfeefc1-9b56-4df3-85df-6cf1b89793ad
Brendel, Julia
c3e4a3bd-7940-42bc-b21c-1461a4f149b9
Eaton, Simon
cf3d8f3d-5ef7-4c78-b57b-19d2357eb431
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf
Thursfield, Rebecca
3d71bbf5-9448-4912-9a84-d2165b92579e
van Heurn, Ernest L.W.
5532bb9b-634e-47c9-82fe-45625908ae89
Ure, Benno
d35d7808-022b-40d0-b32e-762f5b1a61e0
Wijnen, Rene
ac0cf8b0-684a-4d1d-a1d2-3513d40d0bf0
Teunissen, Nadine, Brendel, Julia, Eaton, Simon, Hall, Nigel, Thursfield, Rebecca, van Heurn, Ernest L.W., Ure, Benno and Wijnen, Rene
(2023)
Variability in the reporting of baseline characteristics, treatment, and outcomes in esophageal atresia publications: a systematic review.
European Journal of Pediatric Surgery, 33 (2), .
(doi:10.1055/s-0042-1758828).
Abstract
Introduction: as survival rates of infants born with esophageal atresia (EA) have improved considerably, research interests are shifting from viability to morbidity and longer-term outcomes. This review aims to identify all parameters studied in recent EA research and determine variability in their reporting, utilization, and definition.
Materials and methods: following PRISMA guidelines, we performed a systematic review of literature regarding the main EA care process, published between 2015 and 2021, combining the search term esophageal atresia with morbidity, mortality, survival, outcome, or complication. Described outcomes were extracted from included publications, along with study and baseline characteristics.
Results: from 209 publications that met the inclusion criteria, 731 studied parameters were extracted and categorized into patient characteristics (n = 128), treatment and care process characteristics (n = 338), and outcomes (n = 265). Ninety-two of these were reported in more than 5% of included publications. Most frequently reported characteristics were sex (85%), EA type (74%), and repair type (60%). Most frequently reported outcomes were anastomotic stricture (72%), anastomotic leakage (68%), and mortality (66%).
Conclusion: this study demonstrates considerable heterogeneity of studied parameters in EA research, emphasizing the need for standardized reporting to compare results of EA research. Additionally, the identified items may help develop an informed, evidence-based consensus on outcome measurement in esophageal atresia research and standardized data collection in registries or clinical audits, thereby enabling benchmarking and comparing care between centers, regions, and countries.
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Accepted/In Press date: 4 October 2022
e-pub ahead of print date: 16 February 2023
Published date: 1 April 2023
Additional Information:
Funding Information:
This article is supported by ERNICA. The authors would like to thank the European Pediatric Surgical Audit group (EPSA|ERNICA Registry) for scientific input. Additionally, the authors wish to thank Sabrina T.G. Meertens-Gunput from the Erasmus MC Medical Library for developing and updating the search strategies. And thanks to Ko Hagoort for editing the manuscript. S.E. acknowledges support from the National Institute of Health Research Biomedical Research Centre at Great Ormond Street Hospital.
The EPSA|ERNICA Registry was funded by the European Commission in the 3rd Health Program [HP-PJ-2019].
Keywords:
characteristics, esophageal atresia, outcome
Identifiers
Local EPrints ID: 484673
URI: http://eprints.soton.ac.uk/id/eprint/484673
ISSN: 0939-7248
PURE UUID: 67652af8-4441-493b-8fb1-1cdeaec11087
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Date deposited: 20 Nov 2023 17:39
Last modified: 17 Mar 2024 07:41
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Contributors
Author:
Nadine Teunissen
Author:
Julia Brendel
Author:
Simon Eaton
Author:
Rebecca Thursfield
Author:
Ernest L.W. van Heurn
Author:
Benno Ure
Author:
Rene Wijnen
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