Maternal-placental axis and its impact on fetal outcomes, metabolism, and development
Maternal-placental axis and its impact on fetal outcomes, metabolism, and development
Maternal obesity could impact offspring's health. During "critical period" such as pregnancy insults have a significant role in developing chronic diseases later in life. Literature has shown that diet can play a major role in essential metabolic and development processes on fetal outcomes. Moreover, the placenta, an essential organ developed in pregnancy, seems to have its functions impaired based on pre-gestational and gestational nutritional status. Specifically, a high-fat diet has been shown as a potential nutritional insult that also affects the maternal-placental axis, which is involved in offspring development and outcome. Moreover, some classes of nutrients are associated with pregnancy complications such as reduced intake of micronutrients and diabetes, preeclampsia, and preterm delivery. Thus, we will summarize the current literature on maternal environment factors that impacts the placental development and consequently the fetal an offspring health, or the maternal-placental axis, and this on fetal outcomes, metabolism, and development.
Diet, High-Fat, Female, Fetal Development, Fetus/metabolism, Humans, Infant, Newborn, Placenta/metabolism, Pregnancy, Pregnancy Complications/metabolism, Maternal programming, Metabolic programming, Offspring development, Fetal development, Placenta, Maternal obesity
166855
de Souza Lima, Bruna
9e9710d0-b92a-4ee3-b6d1-7b84bd891190
Sanches, Ana Paula Varela
1e32cab5-ac8a-466a-b607-4c8c4b4c887c
Ferreira, Maíra Schuchter
8a1a4afe-7aae-40b1-9533-d071b19a26a2
de Oliveira, Josilene Lopes
63576433-307e-4abc-acad-36f4559ccfce
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Ignacio-Souza, Letícia
ed678e04-a572-45bd-b39a-f79399677456
January 2024
de Souza Lima, Bruna
9e9710d0-b92a-4ee3-b6d1-7b84bd891190
Sanches, Ana Paula Varela
1e32cab5-ac8a-466a-b607-4c8c4b4c887c
Ferreira, Maíra Schuchter
8a1a4afe-7aae-40b1-9533-d071b19a26a2
de Oliveira, Josilene Lopes
63576433-307e-4abc-acad-36f4559ccfce
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Ignacio-Souza, Letícia
ed678e04-a572-45bd-b39a-f79399677456
de Souza Lima, Bruna, Sanches, Ana Paula Varela, Ferreira, Maíra Schuchter, de Oliveira, Josilene Lopes, Cleal, Jane K. and Ignacio-Souza, Letícia
(2024)
Maternal-placental axis and its impact on fetal outcomes, metabolism, and development.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870 (1), , [166855].
(doi:10.1016/j.bbadis.2023.166855).
Abstract
Maternal obesity could impact offspring's health. During "critical period" such as pregnancy insults have a significant role in developing chronic diseases later in life. Literature has shown that diet can play a major role in essential metabolic and development processes on fetal outcomes. Moreover, the placenta, an essential organ developed in pregnancy, seems to have its functions impaired based on pre-gestational and gestational nutritional status. Specifically, a high-fat diet has been shown as a potential nutritional insult that also affects the maternal-placental axis, which is involved in offspring development and outcome. Moreover, some classes of nutrients are associated with pregnancy complications such as reduced intake of micronutrients and diabetes, preeclampsia, and preterm delivery. Thus, we will summarize the current literature on maternal environment factors that impacts the placental development and consequently the fetal an offspring health, or the maternal-placental axis, and this on fetal outcomes, metabolism, and development.
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Accepted/In Press date: 18 August 2023
e-pub ahead of print date: 24 August 2023
Published date: January 2024
Additional Information:
Funding Information:
This work was supported by São Paulo Research Foundation [grant# 2020/16726-4 , São Paulo Research Foundation (FAPESP)]. This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES, financial Code 001 ); São Paulo Research Foundation (FAPESP, Ignacio-Souza LM grant 2017/11608-0 ); Laboratory of Metabolic Disorders belongs to the Obesity and Comorbidities Research Center and Metabolic Programming and Perinatal Management Center ( NIH 1R01HD099813 ).
Funding Information:
The authors thank Espaço da Escrita – Pró-Reitoria de Pesquisa – UNICAMP – for the language services provided. This work was supported by São Paulo Research Foundation [grant#2020/16726-4, São Paulo Research Foundation (FAPESP)]. This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES, financial Code 001); São Paulo Research Foundation (FAPESP, Ignacio-Souza LM grant 2017/11608-0); Laboratory of Metabolic Disorders belongs to the Obesity and Comorbidities Research Center and Metabolic Programming and Perinatal Management Center (NIH 1R01HD099813).
Publisher Copyright:
© 2023 Elsevier B.V.
Publisher Copyright:
© 2023 Elsevier B.V.
Keywords:
Diet, High-Fat, Female, Fetal Development, Fetus/metabolism, Humans, Infant, Newborn, Placenta/metabolism, Pregnancy, Pregnancy Complications/metabolism, Maternal programming, Metabolic programming, Offspring development, Fetal development, Placenta, Maternal obesity
Identifiers
Local EPrints ID: 484760
URI: http://eprints.soton.ac.uk/id/eprint/484760
ISSN: 0925-4439
PURE UUID: dc61dda5-f674-4418-9e65-c015faa5f618
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Date deposited: 21 Nov 2023 17:34
Last modified: 24 Aug 2024 04:01
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Contributors
Author:
Bruna de Souza Lima
Author:
Ana Paula Varela Sanches
Author:
Maíra Schuchter Ferreira
Author:
Josilene Lopes de Oliveira
Author:
Letícia Ignacio-Souza
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