The University of Southampton
University of Southampton Institutional Repository

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents: a cross-sectional study in Zimbabwe.

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents: a cross-sectional study in Zimbabwe.
Perinatal HIV infection is associated with deficits in muscle function in children and adolescents: a cross-sectional study in Zimbabwe.
Objectives: to determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether anti-retroviral therapy (ART) regime is associated with muscle quality.

Design: a cross-sectional study in Harare, Zimbabwe.

Methods: the study recruited CWH aged 8-16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography. Linear regression calculated adjusted mean differences (aMD) by HIV status.

Results: overall, 303 CWH and 306 without HIV, had mean(SD) age 12.5(2.5) years, BMI 17.5(2.8), with 50% female. Height and fat mass were lower in CWH, mean differences(SE) 7.4(1.1)cm and 2.7(0.4)kgs, respectively. Male CWH had lower grip strength (aMD 2.5[1.1,3.9]kg, p<0.001), long-jump distance (7.1[1.8,12.5]cm, p=0.006), muscle density (0.58[0.12,1.05]mg/cm3, p=0.018, but not lean mass 0.06[-1.08,1.21]kg, p=0.891) versus boys without HIV; differences were consistent but smaller in females. Mediation analysis suggested the negative effect of HIV on jumping power in males was partially mediated by muscle density (p=0.032). CWH taking tenofovir disoproxil fumarate (TDF) had lower muscle density (0.56[0.00,1.13]mg/cm3, p=0.049) independent of fat mass, than CWH on other ART.

Conclusions: perinatally-acquired HIV is associated, particularly in males, with reduced upper and lower-limb muscle function, not mass. Intra-muscular fat (poorer muscle quality) partially explained reductions in lower-limb function. TDF is a novel risk factor for impaired muscle quality.
0269-9370
Gregson, Celia L.
73bbcc0c-aade-4ad6-b386-b85ecf4a339f
Rehman, Andrea M.
70df2a8e-aa95-4942-ad10-4644280f13bf
Rukuni, Ruramayi
c2632960-bd81-4238-b214-a6ec3121f899
Mukwasi-Kahari, Cynthia
72afbd79-2576-4ed7-baa1-205d4e6d8b08
Madanhire, Tafadzwa
24f2c09f-1ee3-4674-9bf6-e201e1d17f6d
Kowo-Nyakoko, Farirayi
5955fed1-6c6f-4602-a003-633a9c8dcd91
Breasail, Micheál Ó.
91913ba1-a694-4365-80f0-dc253cc025c2
Jeena, Lisha
99c60079-fa76-4bfc-b3f5-80ac5a034d26
McHugh, Grace
49956d4d-ba9e-4bc8-84cc-07533f766c19
Filteau, Suzanne
9c7402f1-cd8b-4379-9414-61038a7572f9
Chipanga, Joseph
db3e6475-0578-46f0-94bf-6e776e8fa33d
Simms, Victoria
0ff3eaa5-771c-4699-be49-488bf427ea1d
Mujuru, Hilda
91a774c1-d14c-462b-803b-50be5a7476be
Ward, Kate A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Ferrand, Rashida A.
9441b7cd-4eb5-4665-aa69-357911fd2c87
Gregson, Celia L.
73bbcc0c-aade-4ad6-b386-b85ecf4a339f
Rehman, Andrea M.
70df2a8e-aa95-4942-ad10-4644280f13bf
Rukuni, Ruramayi
c2632960-bd81-4238-b214-a6ec3121f899
Mukwasi-Kahari, Cynthia
72afbd79-2576-4ed7-baa1-205d4e6d8b08
Madanhire, Tafadzwa
24f2c09f-1ee3-4674-9bf6-e201e1d17f6d
Kowo-Nyakoko, Farirayi
5955fed1-6c6f-4602-a003-633a9c8dcd91
Breasail, Micheál Ó.
91913ba1-a694-4365-80f0-dc253cc025c2
Jeena, Lisha
99c60079-fa76-4bfc-b3f5-80ac5a034d26
McHugh, Grace
49956d4d-ba9e-4bc8-84cc-07533f766c19
Filteau, Suzanne
9c7402f1-cd8b-4379-9414-61038a7572f9
Chipanga, Joseph
db3e6475-0578-46f0-94bf-6e776e8fa33d
Simms, Victoria
0ff3eaa5-771c-4699-be49-488bf427ea1d
Mujuru, Hilda
91a774c1-d14c-462b-803b-50be5a7476be
Ward, Kate A.
39bd4db1-c948-4e32-930e-7bec8deb54c7
Ferrand, Rashida A.
9441b7cd-4eb5-4665-aa69-357911fd2c87

Gregson, Celia L., Rehman, Andrea M., Rukuni, Ruramayi, Mukwasi-Kahari, Cynthia, Madanhire, Tafadzwa, Kowo-Nyakoko, Farirayi, Breasail, Micheál Ó., Jeena, Lisha, McHugh, Grace, Filteau, Suzanne, Chipanga, Joseph, Simms, Victoria, Mujuru, Hilda, Ward, Kate A. and Ferrand, Rashida A. (2023) Perinatal HIV infection is associated with deficits in muscle function in children and adolescents: a cross-sectional study in Zimbabwe. AIDS. (doi:10.1097/QAD.0000000000003795).

Record type: Article

Abstract

Objectives: to determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether anti-retroviral therapy (ART) regime is associated with muscle quality.

Design: a cross-sectional study in Harare, Zimbabwe.

Methods: the study recruited CWH aged 8-16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography. Linear regression calculated adjusted mean differences (aMD) by HIV status.

Results: overall, 303 CWH and 306 without HIV, had mean(SD) age 12.5(2.5) years, BMI 17.5(2.8), with 50% female. Height and fat mass were lower in CWH, mean differences(SE) 7.4(1.1)cm and 2.7(0.4)kgs, respectively. Male CWH had lower grip strength (aMD 2.5[1.1,3.9]kg, p<0.001), long-jump distance (7.1[1.8,12.5]cm, p=0.006), muscle density (0.58[0.12,1.05]mg/cm3, p=0.018, but not lean mass 0.06[-1.08,1.21]kg, p=0.891) versus boys without HIV; differences were consistent but smaller in females. Mediation analysis suggested the negative effect of HIV on jumping power in males was partially mediated by muscle density (p=0.032). CWH taking tenofovir disoproxil fumarate (TDF) had lower muscle density (0.56[0.00,1.13]mg/cm3, p=0.049) independent of fat mass, than CWH on other ART.

Conclusions: perinatally-acquired HIV is associated, particularly in males, with reduced upper and lower-limb muscle function, not mass. Intra-muscular fat (poorer muscle quality) partially explained reductions in lower-limb function. TDF is a novel risk factor for impaired muscle quality.

Text
Muscle mass and function r1 2023-10-19-no TCs plus tables - Accepted Manuscript
Restricted to Repository staff only until 22 November 2024.
Available under License Creative Commons Attribution.
Request a copy

More information

Accepted/In Press date: 16 November 2023
e-pub ahead of print date: 22 November 2023

Identifiers

Local EPrints ID: 484765
URI: http://eprints.soton.ac.uk/id/eprint/484765
ISSN: 0269-9370
PURE UUID: bd08283a-2bfd-40b8-b4a9-a61c34f4fa0d
ORCID for Kate A. Ward: ORCID iD orcid.org/0000-0001-7034-6750

Catalogue record

Date deposited: 21 Nov 2023 17:37
Last modified: 02 Feb 2024 02:48

Export record

Altmetrics

Contributors

Author: Celia L. Gregson
Author: Andrea M. Rehman
Author: Ruramayi Rukuni
Author: Cynthia Mukwasi-Kahari
Author: Tafadzwa Madanhire
Author: Farirayi Kowo-Nyakoko
Author: Micheál Ó. Breasail
Author: Lisha Jeena
Author: Grace McHugh
Author: Suzanne Filteau
Author: Joseph Chipanga
Author: Victoria Simms
Author: Hilda Mujuru
Author: Kate A. Ward ORCID iD
Author: Rashida A. Ferrand

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×