Micronutrient status in adult Crohn’s disease during clinical remission: a systematic review
Micronutrient status in adult Crohn’s disease during clinical remission: a systematic review
Adults with Crohn’s disease (CD) may be at risk of micronutrient insufficiency in clinical remission through restrictive eating, malabsorption, abnormal losses or inflammation. This systematic review synthesises the literature on micronutrient insufficiency in CD in clinical remission in terms of the prevalence of low circulating micronutrient concentrations and as a comparison against a healthy control (HC). Studies were included if the population was predominantly in remission. A total of 42 studies met the inclusion criteria; 12 were rated as low quality, leaving 30 studies covering 21 micronutrients of medium/high quality that were included in the synthesis. Vitamins D and B12 were the most frequently reported nutrients (8 and 11); there were few eligible studies for the remaining micronutrients. The prevalence studies were consistent in reporting individuals with low Vitamins A, B6, B12 and C, β-carotene, D, Magnesium, Selenium and Zinc. The comparator studies were inconsistent in finding differences with CD populations; Vitamin D, the most reported nutrient, was only lower than the HC in one-quarter of the studies. Adult CD populations are likely to contain individuals with low levels of one or more micronutrients, with the most substantial evidence for Vitamins D and B12. The studies on other micronutrients are of insufficient number, standardisation and quality to inform practice.
Crohn’s disease, inflammatory bowel diseases, micronutrient deficiency, micronutrient insufficiency, micronutrients, minerals, review, trace elements, vitamin
McDonnell, Martin
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Sartain, Stephanie
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Westoby, Catherine
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Katarachia, Vasiliki
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Wootton, Stephen A.
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Cummings, J.R. Fraser
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November 2023
McDonnell, Martin
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Sartain, Stephanie
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Westoby, Catherine
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Katarachia, Vasiliki
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Wootton, Stephen A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Cummings, J.R. Fraser
9e0868f8-6980-4925-b474-345e478066b4
McDonnell, Martin, Sartain, Stephanie, Westoby, Catherine, Katarachia, Vasiliki, Wootton, Stephen A. and Cummings, J.R. Fraser
(2023)
Micronutrient status in adult Crohn’s disease during clinical remission: a systematic review.
Nutrients, 15 (22), [4777].
(doi:10.3390/nu15224777).
Abstract
Adults with Crohn’s disease (CD) may be at risk of micronutrient insufficiency in clinical remission through restrictive eating, malabsorption, abnormal losses or inflammation. This systematic review synthesises the literature on micronutrient insufficiency in CD in clinical remission in terms of the prevalence of low circulating micronutrient concentrations and as a comparison against a healthy control (HC). Studies were included if the population was predominantly in remission. A total of 42 studies met the inclusion criteria; 12 were rated as low quality, leaving 30 studies covering 21 micronutrients of medium/high quality that were included in the synthesis. Vitamins D and B12 were the most frequently reported nutrients (8 and 11); there were few eligible studies for the remaining micronutrients. The prevalence studies were consistent in reporting individuals with low Vitamins A, B6, B12 and C, β-carotene, D, Magnesium, Selenium and Zinc. The comparator studies were inconsistent in finding differences with CD populations; Vitamin D, the most reported nutrient, was only lower than the HC in one-quarter of the studies. Adult CD populations are likely to contain individuals with low levels of one or more micronutrients, with the most substantial evidence for Vitamins D and B12. The studies on other micronutrients are of insufficient number, standardisation and quality to inform practice.
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nutrients-15-04777
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Accepted/In Press date: 9 November 2023
e-pub ahead of print date: 14 November 2023
Published date: November 2023
Additional Information:
Funding Information:
This work was undertaken whilst M.M. was completing pre-doctoral studies as part of an investigator-led research collaborative research agreement between Nestlé Health Sciences, University Hospital Southampton and the University of Southampton (cost centre 701543). Nestlé played no part in the design, conduct or interpretation of the work reported in this publication.
Publisher Copyright:
© 2023 by the authors.
Keywords:
Crohn’s disease, inflammatory bowel diseases, micronutrient deficiency, micronutrient insufficiency, micronutrients, minerals, review, trace elements, vitamin
Identifiers
Local EPrints ID: 484788
URI: http://eprints.soton.ac.uk/id/eprint/484788
ISSN: 2072-6643
PURE UUID: 647b949e-9770-438a-945f-394469028895
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Date deposited: 21 Nov 2023 17:53
Last modified: 17 Mar 2024 05:57
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Contributors
Author:
Martin McDonnell
Author:
Stephanie Sartain
Author:
Catherine Westoby
Author:
Vasiliki Katarachia
Author:
J.R. Fraser Cummings
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