Protocol for open-label randomized clinical trial of intensive surveillance versus standard postoperative follow-up in patients undergoing surgical resection for oesophageal and gastric cancer

Markar, Sheraz R, Guazzelli, Alice, Taylor, Amy, Jones, Laura Lloyd, Dutton, Susan, Jogarah, Vidoushee, Brittain, Clare, Maynard, Nick, Cromwell, David, Landeiro, Filipa, Underwood, Tim, Lagergren, Jesper, Gleeson, Fergus, Moss, Alan and Crosby, Tom , the SARONG study group (2023) Protocol for open-label randomized clinical trial of intensive surveillance versus standard postoperative follow-up in patients undergoing surgical resection for oesophageal and gastric cancer. British Journal of Surgery, 110 (10), 1359-1360. (doi:10.1093/bjs/znad180).

Abstract

Despite recent improvements in oncological and surgical treatment for patients with oesophageal and gastric cancer, 60 per cent of those with locally advanced disease who are treated with curative intent will develop tumour recurrence and die within 3 years of completing treatment. In the absence of robust scientific evidence, national or international guidelines have failed to reach consensus on the optimal surveillance strategy after primary treatment of oesophageal or gastric cancer.
The primary research question of the proposed RCT is: does the routine use of a structured follow-up programme with regular radiological and endoscopic investigations improve survival in patients who have had surgical treatment for oesophageal or gastric cancer with curative intent?

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Contributors

Author: Tim Underwood

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