Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system
Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system
In a continuous flow process, generating a gradient of solvent composition with time and monitoring of the reaction mixture as it leaves the reactor allows for rapid generation of reaction information against a full range of solvent mixture compositions. The methodology was developed by screening binary solvent mixtures in a SNAr reaction in which previously reported effects were efficiently reproduced. Binary and ternary solvent gradients were then applied to an imine forming reaction revealing interesting non-linear effects.
Drelinkiewicz, Dawid
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Corrie, Tom J.A.
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Whitby, Richard J.
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Drelinkiewicz, Dawid
fee337f9-b562-4542-a9f2-6a5c583ebc7d
Corrie, Tom J.A.
3175c1f8-6569-4181-b196-1839110fa517
Whitby, Richard J.
45632236-ab00-4ad0-a02d-6209043e818b
Drelinkiewicz, Dawid, Corrie, Tom J.A. and Whitby, Richard J.
(2023)
Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system.
Reaction Chemistry and Engineering.
(doi:10.1039/d3re00464c).
Abstract
In a continuous flow process, generating a gradient of solvent composition with time and monitoring of the reaction mixture as it leaves the reactor allows for rapid generation of reaction information against a full range of solvent mixture compositions. The methodology was developed by screening binary solvent mixtures in a SNAr reaction in which previously reported effects were efficiently reproduced. Binary and ternary solvent gradients were then applied to an imine forming reaction revealing interesting non-linear effects.
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d3re00464c
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Accepted/In Press date: 11 October 2023
e-pub ahead of print date: 19 October 2023
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Funding Information:
We wish to thank Vapourtec Ltd for their excellent customer service. We are grateful to Syngenta (Jeallot's Hill) and a Southampton University Vice-Chancellors award for funding this work. Research infrastructure was supported by EPSRC (UK) core capability grant (EP/K039466).
Publisher Copyright:
© 2023 The Royal Society of Chemistry
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Local EPrints ID: 484819
URI: http://eprints.soton.ac.uk/id/eprint/484819
ISSN: 2058-9883
PURE UUID: 9640ef4d-a756-4399-b07d-02a8630da9b8
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Date deposited: 22 Nov 2023 17:35
Last modified: 18 Mar 2024 03:54
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Author:
Dawid Drelinkiewicz
Author:
Tom J.A. Corrie
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