The University of Southampton
University of Southampton Institutional Repository

Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG)

Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG)
Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG)
Purpose: To compare quality of survival after craniospinal irradiation (CSI) alone with survival after CSI plus chemotherapy (CT) for medulloblastoma.
Patients and Methods: Follow-up study of surviving UK patients with medulloblastoma diagnosed between 1992 and 2000 treated according to one or other treatment arm of the PNET 3 controlled trial.
Results: Seventy three percent of all 147 eligible patients ages 6.6 to 24.3 years were assessed at a mean of 7.2 years after diagnosis. Health status was significantly poorer in the group treated in the CSI plus CT arm of the trial than in the CSI alone arm, and there were also trends to poorer outcomes for behavior and quality of life scores. The CSI plus CT group were also significantly more restricted physically and needed more therapeutic and educational support. Body mass index, stature, and other endocrine outcomes were similar in the two treatment arms, except for the trend in increased frequency of medical induction of puberty in the CSI plus CT group.
Conclusion: The addition of CT to CSI for medulloblastoma was associated with a significant decrease in health status. The effect of the addition of other CT regimens to CSI on quality of survival should be evaluated.
1527-7755
4239-4245
Bull, K.S.
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Spoudeas, H.A.
e9c1078c-3d73-4663-bbac-b62e80eba0db
Yadegarfar, G.
e1e5c022-335f-47dc-b5e9-4c804f253a8b
Kennedy, C.R.
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
CCLG
Bull, K.S.
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Spoudeas, H.A.
e9c1078c-3d73-4663-bbac-b62e80eba0db
Yadegarfar, G.
e1e5c022-335f-47dc-b5e9-4c804f253a8b
Kennedy, C.R.
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93

Bull, K.S., Spoudeas, H.A., Yadegarfar, G. and Kennedy, C.R. , CCLG (2007) Reduction of health status 7 years after addition of chemotherapy to craniospinal irradiation for medulloblastoma: a follow-up study in PNET 3 trial survivors on behalf of the CCLG (formerly UKCCSG). Journal of Clinical Oncology, 25 (27), 4239-4245. (doi:10.1200/JCO.2006.08.7684).

Record type: Article

Abstract

Purpose: To compare quality of survival after craniospinal irradiation (CSI) alone with survival after CSI plus chemotherapy (CT) for medulloblastoma.
Patients and Methods: Follow-up study of surviving UK patients with medulloblastoma diagnosed between 1992 and 2000 treated according to one or other treatment arm of the PNET 3 controlled trial.
Results: Seventy three percent of all 147 eligible patients ages 6.6 to 24.3 years were assessed at a mean of 7.2 years after diagnosis. Health status was significantly poorer in the group treated in the CSI plus CT arm of the trial than in the CSI alone arm, and there were also trends to poorer outcomes for behavior and quality of life scores. The CSI plus CT group were also significantly more restricted physically and needed more therapeutic and educational support. Body mass index, stature, and other endocrine outcomes were similar in the two treatment arms, except for the trend in increased frequency of medical induction of puberty in the CSI plus CT group.
Conclusion: The addition of CT to CSI for medulloblastoma was associated with a significant decrease in health status. The effect of the addition of other CT regimens to CSI on quality of survival should be evaluated.

Full text not available from this repository.

More information

Published date: 20 September 2007

Identifiers

Local EPrints ID: 48489
URI: https://eprints.soton.ac.uk/id/eprint/48489
ISSN: 1527-7755
PURE UUID: 3b518ab9-fe94-4130-ad39-59fb281a404b
ORCID for K.S. Bull: ORCID iD orcid.org/0000-0002-5541-4556

Catalogue record

Date deposited: 26 Sep 2007
Last modified: 14 Mar 2019 01:48

Export record

Altmetrics

Contributors

Author: K.S. Bull ORCID iD
Author: H.A. Spoudeas
Author: G. Yadegarfar
Author: C.R. Kennedy

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×