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Long-term benefit of IGHV mutated patients in a real-life multicenter cohort of FCR-treated chronic lymphocytic leukemia

Long-term benefit of IGHV mutated patients in a real-life multicenter cohort of FCR-treated chronic lymphocytic leukemia
Long-term benefit of IGHV mutated patients in a real-life multicenter cohort of FCR-treated chronic lymphocytic leukemia
Fludarabine, cyclophosphamide and rituximab (FCR) has been the standard of care for first-line chronic lymphocytic leukemia (CLL) treatment for more than a decade and the latest European Society for Medical Oncology guidelines still consider FCR a therapeutic option for immunoglobulin heavy-chain variable region gene (IGHV) mutated patients devoid of TP53 disruption.1 During the last few years, however, the therapeutic scenario of CLL has changed toward chemo-free strategies with pathway inhibitors.2, 3 Because the median age of patients at CLL diagnosis is 72 years, this leukemia affects mainly elderly individuals and its prevalence is closely linked to the population life expectancy.
0278-0232
567 - 570
Moia, Riccardo
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Dondolin, Riccardo
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De Propris, Maria Stefania
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Talotta, Donatella
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Mouhssine, Samir
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Perutelli, Francesca
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Reda, Gianluigi
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Mattiello, Veronica
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Rigolin, Gian Matteo
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Motta, Marina
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Olivieri, Jacopo
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Fanin, Renato
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Perbellini, Omar
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Ferrarini, Isacco
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Mauro, Francesca Romana
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Del Giudice, Ilaria
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Laurenti, Luca
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Tomasso, Annamaria
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Gentile, Massimo
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Frustaci, Anna Maria
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Tedeschi, Alessandra
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Gozzetti, Alessandro
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Stelitano, Caterina
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Visco, Carlo
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Moreno, Carol
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Forconi, Francesco
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Marasca, Roberto
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Coscia, Marta
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Rossi, Davide
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Foà, Robin
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Gaidano, Gianluca
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et al.
Moia, Riccardo
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Dondolin, Riccardo
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De Propris, Maria Stefania
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Talotta, Donatella
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Mouhssine, Samir
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Perutelli, Francesca
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Reda, Gianluigi
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Mattiello, Veronica
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Rigolin, Gian Matteo
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Motta, Marina
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Olivieri, Jacopo
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Fanin, Renato
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Perbellini, Omar
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Ferrarini, Isacco
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Mauro, Francesca Romana
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Del Giudice, Ilaria
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Laurenti, Luca
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Tomasso, Annamaria
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Gentile, Massimo
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Frustaci, Anna Maria
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Tedeschi, Alessandra
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Gozzetti, Alessandro
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Stelitano, Caterina
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Visco, Carlo
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Moreno, Carol
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Forconi, Francesco
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Marasca, Roberto
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Coscia, Marta
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Rossi, Davide
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Foà, Robin
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Gaidano, Gianluca
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Moia, Riccardo, Dondolin, Riccardo, De Propris, Maria Stefania and Forconi, Francesco , et al. (2022) Long-term benefit of IGHV mutated patients in a real-life multicenter cohort of FCR-treated chronic lymphocytic leukemia. Hematological Oncology, 41 (3), 567 - 570. (doi:10.1002/hon.3080).

Record type: Letter

Abstract

Fludarabine, cyclophosphamide and rituximab (FCR) has been the standard of care for first-line chronic lymphocytic leukemia (CLL) treatment for more than a decade and the latest European Society for Medical Oncology guidelines still consider FCR a therapeutic option for immunoglobulin heavy-chain variable region gene (IGHV) mutated patients devoid of TP53 disruption.1 During the last few years, however, the therapeutic scenario of CLL has changed toward chemo-free strategies with pathway inhibitors.2, 3 Because the median age of patients at CLL diagnosis is 72 years, this leukemia affects mainly elderly individuals and its prevalence is closely linked to the population life expectancy.

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More information

Accepted/In Press date: 3 October 2022
e-pub ahead of print date: 10 October 2022
Additional Information: Funding Information: This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC), Special 5x1000 Program Metastases (21198), Milan (Italy); Progetti di Rilevante Interesse Nazionale (PRIN; 2015ZMRFEA), Rome, Italy; the AGING Project – Department of Excellence – DIMET, Università del Piemonte Orientale, Novara, Italy; and Ricerca Finalizzata 2018 (project RF‐2018‐12365790), MoH, Rome, Italy; AIL Novara ONLUS.

Identifiers

Local EPrints ID: 484951
URI: http://eprints.soton.ac.uk/id/eprint/484951
DOI: doi:10.1002/hon.3080
ISSN: 0278-0232
PURE UUID: 01026602-77d0-43a9-aa88-b023d0c5bddc
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831

Catalogue record

Date deposited: 24 Nov 2023 18:05
Last modified: 17 Mar 2024 03:27

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Contributors

Author: Riccardo Moia
Author: Riccardo Dondolin
Author: Maria Stefania De Propris
Author: Donatella Talotta
Author: Samir Mouhssine
Author: Francesca Perutelli
Author: Gianluigi Reda
Author: Veronica Mattiello
Author: Gian Matteo Rigolin
Author: Marina Motta
Author: Jacopo Olivieri
Author: Renato Fanin
Author: Omar Perbellini
Author: Isacco Ferrarini
Author: Francesca Romana Mauro
Author: Ilaria Del Giudice
Author: Luca Laurenti
Author: Annamaria Tomasso
Author: Massimo Gentile
Author: Anna Maria Frustaci
Author: Alessandra Tedeschi
Author: Alessandro Gozzetti
Author: Caterina Stelitano
Author: Carlo Visco
Author: Carol Moreno
Author: Francesco Forconi ORCID iD
Author: Roberto Marasca
Author: Marta Coscia
Author: Davide Rossi
Author: Robin Foà
Author: Gianluca Gaidano
Corporate Author: et al.

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