Prevalence and clinical implications of respiratory viruses in asthma during stable disease state and acute attacks: protocol for a meta-analysis
Prevalence and clinical implications of respiratory viruses in asthma during stable disease state and acute attacks: protocol for a meta-analysis
Introduction: viruses are detected in over 50% of acute asthma attacks and in a notable proportion of patients with asthma during stable disease state They are associated with worse outcomes. We will conduct a series of systematic reviews and meta-analyses to quantify the prevalence and clinical burden of various respiratory viruses in stable asthma and acute asthma attacks. In addition, we will assess the viral loads of respiratory viruses during stable and acute asthma, to explore whether viral load could differentiate attacks triggered by viruses versus those where viruses are present as "innocent bystanders".
Materials and methods: based on a prospectively registered protocol (PROSPERO, ID: CRD42023375108) and following standard methodology recommended by Cochrane, we will systematically search Medline/PubMed, EMBASE, the Cochrane Library and relevant conference proceedings for studies assessing the prevalence or clinical burden of respiratory viruses in asthma. Methodological rigour of the included studies will be appraised using a tool specific for prevalence studies and the Newcastle-Ottawa Scale respectively. In anticipation of significant clinical and methodological heterogeneity, we will conduct random effect meta-analyses. For evaluating the prevalence of viruses, we will perform meta-analyses of proportions using the inverse variance method, and the Freeman-Tukey transformation. We will conduct meta-regression analyses for exploring heterogeneity.
Conclusion: we envisage that these systematic reviews and meta-analyses will quantify the prevalence and burden of respiratory viruses in stable and acute asthma and will drive future research and clinical practice.
Asthma/epidemiology, Cross-Sectional Studies, Humans, Meta-Analysis as Topic, Prevalence, Systematic Reviews as Topic, Viruses
Alimani, Gioulinta S.
5b8f9b86-cdbb-4f1d-b357-43e8a8dbd600
Ananth, Sachin
b69358c1-073d-44de-a79c-8e511a9419a6
Boccabella, Cristina
0bbf0534-c036-4ce5-96be-31e7bbb1db56
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Papadopoulos, Nikolaos G.
bb0da82a-300e-44b9-ba26-3573d81f48be
Kosmidis, Chris
dd9e1739-5582-473f-ae58-e7cf7a455c49
Vestbo, Jørgen
6298f58b-134a-4dc5-b560-2b7eb261965f
Papageorgiou, Effie
946611f9-704e-4857-bf05-d1052cd2717e
Beloukas, Apostolos
8ad81553-12f1-47a6-854c-a1d6317c4368
Mathioudakis, Alexander G.
ffbdd50a-79dc-439a-8c88-f25b4a004d45
Alimani, Gioulinta S.
5b8f9b86-cdbb-4f1d-b357-43e8a8dbd600
Ananth, Sachin
b69358c1-073d-44de-a79c-8e511a9419a6
Boccabella, Cristina
0bbf0534-c036-4ce5-96be-31e7bbb1db56
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Papadopoulos, Nikolaos G.
bb0da82a-300e-44b9-ba26-3573d81f48be
Kosmidis, Chris
dd9e1739-5582-473f-ae58-e7cf7a455c49
Vestbo, Jørgen
6298f58b-134a-4dc5-b560-2b7eb261965f
Papageorgiou, Effie
946611f9-704e-4857-bf05-d1052cd2717e
Beloukas, Apostolos
8ad81553-12f1-47a6-854c-a1d6317c4368
Mathioudakis, Alexander G.
ffbdd50a-79dc-439a-8c88-f25b4a004d45
Alimani, Gioulinta S., Ananth, Sachin, Boccabella, Cristina, Khaleva, Ekaterina, Roberts, Graham, Papadopoulos, Nikolaos G., Kosmidis, Chris, Vestbo, Jørgen, Papageorgiou, Effie, Beloukas, Apostolos and Mathioudakis, Alexander G.
(2023)
Prevalence and clinical implications of respiratory viruses in asthma during stable disease state and acute attacks: protocol for a meta-analysis.
PLoS ONE, 18 (11 November), [e0294416].
(doi:10.1371/journal.pone.0294416).
Abstract
Introduction: viruses are detected in over 50% of acute asthma attacks and in a notable proportion of patients with asthma during stable disease state They are associated with worse outcomes. We will conduct a series of systematic reviews and meta-analyses to quantify the prevalence and clinical burden of various respiratory viruses in stable asthma and acute asthma attacks. In addition, we will assess the viral loads of respiratory viruses during stable and acute asthma, to explore whether viral load could differentiate attacks triggered by viruses versus those where viruses are present as "innocent bystanders".
Materials and methods: based on a prospectively registered protocol (PROSPERO, ID: CRD42023375108) and following standard methodology recommended by Cochrane, we will systematically search Medline/PubMed, EMBASE, the Cochrane Library and relevant conference proceedings for studies assessing the prevalence or clinical burden of respiratory viruses in asthma. Methodological rigour of the included studies will be appraised using a tool specific for prevalence studies and the Newcastle-Ottawa Scale respectively. In anticipation of significant clinical and methodological heterogeneity, we will conduct random effect meta-analyses. For evaluating the prevalence of viruses, we will perform meta-analyses of proportions using the inverse variance method, and the Freeman-Tukey transformation. We will conduct meta-regression analyses for exploring heterogeneity.
Conclusion: we envisage that these systematic reviews and meta-analyses will quantify the prevalence and burden of respiratory viruses in stable and acute asthma and will drive future research and clinical practice.
Text
journal.pone.0294416
- Version of Record
More information
Accepted/In Press date: 31 October 2023
e-pub ahead of print date: 15 November 2023
Additional Information:
Publisher Copyright:
Copyright: © 2023 Alimani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords:
Asthma/epidemiology, Cross-Sectional Studies, Humans, Meta-Analysis as Topic, Prevalence, Systematic Reviews as Topic, Viruses
Identifiers
Local EPrints ID: 484953
URI: http://eprints.soton.ac.uk/id/eprint/484953
ISSN: 1932-6203
PURE UUID: 58689d67-6bc4-4f78-8170-a4e3e6d7d64a
Catalogue record
Date deposited: 27 Nov 2023 17:30
Last modified: 17 Aug 2024 02:05
Export record
Altmetrics
Contributors
Author:
Gioulinta S. Alimani
Author:
Sachin Ananth
Author:
Cristina Boccabella
Author:
Ekaterina Khaleva
Author:
Nikolaos G. Papadopoulos
Author:
Chris Kosmidis
Author:
Jørgen Vestbo
Author:
Effie Papageorgiou
Author:
Apostolos Beloukas
Author:
Alexander G. Mathioudakis
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics