Microfluidic NMR for in situ culture and metabolomic analysis of hepatocellular carcinoma cell lines
Microfluidic NMR for in situ culture and metabolomic analysis of hepatocellular carcinoma cell lines
We demonstrate the use of microfluidic NMR for in situ culture and continuous quantitative analysis of metabolism in hepatocellular carcinoma (HCC) cell lines. The ability to observe intracellular responses in a time-resolved manner provides a more detailed view of a biological system and how it reacts to stimuli. This has significant potential in the pharmaceutical field for drug development, particularly toxicity testing.
Hepatocellular carcinoma (HCC), Metabolism, Microfluidic NMR (μNMR)
330-331
Rogers, Evie
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Barker, Sylwia
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Sharma, Manvendra
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Patra, Bishnubrata
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Khakoo, Salim
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Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
2022
Rogers, Evie
59329698-ec54-4b20-8503-f73c67b08c5b
Barker, Sylwia
e43994fe-2f73-41c8-b197-f56a8e00ea5e
Sharma, Manvendra
e249236d-221d-4e59-8440-011f6863f891
Patra, Bishnubrata
3bfe5fe9-78ef-4026-9f42-2dd75cfea3b2
Khakoo, Salim
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Rogers, Evie, Barker, Sylwia, Sharma, Manvendra, Patra, Bishnubrata, Khakoo, Salim and Utz, Marcel
(2022)
Microfluidic NMR for in situ culture and metabolomic analysis of hepatocellular carcinoma cell lines.
In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences.
The Printing House.
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Conference or Workshop Item
(Paper)
Abstract
We demonstrate the use of microfluidic NMR for in situ culture and continuous quantitative analysis of metabolism in hepatocellular carcinoma (HCC) cell lines. The ability to observe intracellular responses in a time-resolved manner provides a more detailed view of a biological system and how it reacts to stimuli. This has significant potential in the pharmaceutical field for drug development, particularly toxicity testing.
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PG0330
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Available under License Other.
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Published date: 2022
Additional Information:
Funding Information: we are grateful for funding from Cancer Research UK, as a part of the HUNTER consortium, and the Institute for Life Sciences, Southampton.
Venue - Dates:
26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Hangzhou International Expo Center, Hangzhou, China, 2022-10-23 - 2022-10-27
Keywords:
Hepatocellular carcinoma (HCC), Metabolism, Microfluidic NMR (μNMR)
Identifiers
Local EPrints ID: 485017
URI: http://eprints.soton.ac.uk/id/eprint/485017
PURE UUID: c09e7edf-e31b-4dde-9c5c-3114056ab817
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Date deposited: 28 Nov 2023 17:36
Last modified: 06 Jun 2024 02:13
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Contributors
Author:
Evie Rogers
Author:
Sylwia Barker
Author:
Manvendra Sharma
Author:
Bishnubrata Patra
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