The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.
7pp
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
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Tare, Rahul
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Andar, Abhay
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Riehle, Mathis O.
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Herzyk, Pawel
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Wilkinson, Chris D.W.
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Oreffo, Richard O.C.
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23 September 2007
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
bf72c3d1-e6a7-48b4-a968-c496b655bd98
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Andar, Abhay
d7819f77-6ca3-4bc5-a547-c4d05101b623
Riehle, Mathis O.
ceb7d4d2-8d2d-41be-b3e5-7dae7a331bae
Herzyk, Pawel
cef75f09-fa0b-4da4-9050-37df18da040b
Wilkinson, Chris D.W.
ea556659-2ba1-43a8-b8d3-37e4bfaffd41
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dalby, Matthew J., Gadegaard, Nikolaj, Tare, Rahul, Andar, Abhay, Riehle, Mathis O., Herzyk, Pawel, Wilkinson, Chris D.W. and Oreffo, Richard O.C.
(2007)
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.
Nature Materials, 6, .
(doi:10.1038/nmat2013).
Abstract
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.
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Published date: 23 September 2007
Additional Information:
Epublish ahead of print
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Local EPrints ID: 48504
URI: http://eprints.soton.ac.uk/id/eprint/48504
ISSN: 1476-1122
PURE UUID: 1a43c41a-7629-430b-9605-dca7204b177f
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Date deposited: 26 Sep 2007
Last modified: 16 Mar 2024 03:39
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Contributors
Author:
Matthew J. Dalby
Author:
Nikolaj Gadegaard
Author:
Abhay Andar
Author:
Mathis O. Riehle
Author:
Pawel Herzyk
Author:
Chris D.W. Wilkinson
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