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The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

Dalby, Matthew J., Gadegaard, Nikolaj, Tare, Rahul, Andar, Abhay, Riehle, Mathis O., Herzyk, Pawel, Wilkinson, Chris D.W. and Oreffo, Richard O.C. (2007) The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder Nature Materials, 6, 7pp. (doi:10.1038/nmat2013).

Record type: Article


A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.

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Published date: 23 September 2007
Additional Information: Epublish ahead of print


Local EPrints ID: 48504
ISSN: 1476-1122
PURE UUID: 1a43c41a-7629-430b-9605-dca7204b177f
ORCID for Rahul Tare: ORCID iD
ORCID for Richard O.C. Oreffo: ORCID iD

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Date deposited: 26 Sep 2007
Last modified: 17 Jul 2017 14:59

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Author: Matthew J. Dalby
Author: Nikolaj Gadegaard
Author: Rahul Tare ORCID iD
Author: Abhay Andar
Author: Mathis O. Riehle
Author: Pawel Herzyk
Author: Chris D.W. Wilkinson

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