The University of Southampton
University of Southampton Institutional Repository

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.
1476-1122
7pp
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
bf72c3d1-e6a7-48b4-a968-c496b655bd98
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Andar, Abhay
d7819f77-6ca3-4bc5-a547-c4d05101b623
Riehle, Mathis O.
ceb7d4d2-8d2d-41be-b3e5-7dae7a331bae
Herzyk, Pawel
cef75f09-fa0b-4da4-9050-37df18da040b
Wilkinson, Chris D.W.
ea556659-2ba1-43a8-b8d3-37e4bfaffd41
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
bf72c3d1-e6a7-48b4-a968-c496b655bd98
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Andar, Abhay
d7819f77-6ca3-4bc5-a547-c4d05101b623
Riehle, Mathis O.
ceb7d4d2-8d2d-41be-b3e5-7dae7a331bae
Herzyk, Pawel
cef75f09-fa0b-4da4-9050-37df18da040b
Wilkinson, Chris D.W.
ea556659-2ba1-43a8-b8d3-37e4bfaffd41
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Dalby, Matthew J., Gadegaard, Nikolaj, Tare, Rahul, Andar, Abhay, Riehle, Mathis O., Herzyk, Pawel, Wilkinson, Chris D.W. and Oreffo, Richard O.C. (2007) The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Materials, 6, 7pp. (doi:10.1038/nmat2013).

Record type: Article

Abstract

A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.

Text
nmat2013.pdf - Version of Record
Restricted to Repository staff only
Request a copy

More information

Published date: 23 September 2007
Additional Information: Epublish ahead of print

Identifiers

Local EPrints ID: 48504
URI: http://eprints.soton.ac.uk/id/eprint/48504
ISSN: 1476-1122
PURE UUID: 1a43c41a-7629-430b-9605-dca7204b177f
ORCID for Rahul Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 26 Sep 2007
Last modified: 16 Mar 2024 03:39

Export record

Altmetrics

Contributors

Author: Matthew J. Dalby
Author: Nikolaj Gadegaard
Author: Rahul Tare ORCID iD
Author: Abhay Andar
Author: Mathis O. Riehle
Author: Pawel Herzyk
Author: Chris D.W. Wilkinson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×