Point-wise correlations between 10-2 Humphrey visual field and OCT data in open angle glaucoma
Point-wise correlations between 10-2 Humphrey visual field and OCT data in open angle glaucoma
Purpose: optical Coherence Tomography (OCT) is a powerful instrument for helping clinicians detect and monitor glaucoma. The aim of this study was to provide a detailed mapping of the relationships between visual field (VF) sensitivities and measures of retinal structure provided by a commercial Spectral Domain (SD)-OCT system (RTvue-100 Optovue).
Methods: sixty-three eyes of open angle glaucoma patients (17 males, 16 females, and mean age 71 ± 7.5 years) were included in this retrospective, observational clinical study. Thickness values for superior and inferior retina, as well as average values, were recorded for the full retina, the outer retina, the ganglion cell complex, and the peripapillary retinal nerve fiber layer (RNFL). RNFL thickness was further evaluated along eight separate sectors (temporal lower, temporal upper, superior temporal, superior nasal, nasal upper, nasal lower, inferior nasal, and inferior temporal). Point-wise correlations were then computed between each of these OCT measures and the visual sensitivities at all VF locations assessed via Humphrey 10-2 and 24-2 perimetry. Lastly, OCT data were fit to VF data to predict glaucoma stage.
Results: the relationship between retinal thickness and visual sensitivities reflects the known topography of the retina. Spatial correlation patterns between visual sensitivities and RNFL thickness along different sectors broadly agree with previously hypothesized structure–function maps, yet suggest that structure–function maps still require more precise characterizations. Given these relationships, we find that OCT data can predict glaucoma stage.
Conclusion: ganglion cell complex and RNFL thickness measurements are highlighted as the most promising candidate metrics for glaucoma detection and monitoring.
868-876
Cirafici, Paola
5149bba5-a2c9-4d91-bc24-d40eae3026b1
Maiello, Guido
c122b089-1bbc-4d3e-b178-b0a1b31a5295
Ancona, Chiara
3b63c416-b0aa-4ec1-8113-0ad4beecc05b
Masala, Alessandro
c1e0aee6-4a85-49b1-a498-19dc0ea824b5
Traverso, Carlo Enrico
f23534b9-0ad9-4d2b-974b-7c7cf8d9fbfc
Iester, Michele
96738d7f-a9be-4f38-b112-2ea48fafebd8
March 2021
Cirafici, Paola
5149bba5-a2c9-4d91-bc24-d40eae3026b1
Maiello, Guido
c122b089-1bbc-4d3e-b178-b0a1b31a5295
Ancona, Chiara
3b63c416-b0aa-4ec1-8113-0ad4beecc05b
Masala, Alessandro
c1e0aee6-4a85-49b1-a498-19dc0ea824b5
Traverso, Carlo Enrico
f23534b9-0ad9-4d2b-974b-7c7cf8d9fbfc
Iester, Michele
96738d7f-a9be-4f38-b112-2ea48fafebd8
Cirafici, Paola, Maiello, Guido, Ancona, Chiara, Masala, Alessandro, Traverso, Carlo Enrico and Iester, Michele
(2021)
Point-wise correlations between 10-2 Humphrey visual field and OCT data in open angle glaucoma.
Eye (Basingstoke), 35, .
(doi:10.1038/s41433-020-0989-7).
Abstract
Purpose: optical Coherence Tomography (OCT) is a powerful instrument for helping clinicians detect and monitor glaucoma. The aim of this study was to provide a detailed mapping of the relationships between visual field (VF) sensitivities and measures of retinal structure provided by a commercial Spectral Domain (SD)-OCT system (RTvue-100 Optovue).
Methods: sixty-three eyes of open angle glaucoma patients (17 males, 16 females, and mean age 71 ± 7.5 years) were included in this retrospective, observational clinical study. Thickness values for superior and inferior retina, as well as average values, were recorded for the full retina, the outer retina, the ganglion cell complex, and the peripapillary retinal nerve fiber layer (RNFL). RNFL thickness was further evaluated along eight separate sectors (temporal lower, temporal upper, superior temporal, superior nasal, nasal upper, nasal lower, inferior nasal, and inferior temporal). Point-wise correlations were then computed between each of these OCT measures and the visual sensitivities at all VF locations assessed via Humphrey 10-2 and 24-2 perimetry. Lastly, OCT data were fit to VF data to predict glaucoma stage.
Results: the relationship between retinal thickness and visual sensitivities reflects the known topography of the retina. Spatial correlation patterns between visual sensitivities and RNFL thickness along different sectors broadly agree with previously hypothesized structure–function maps, yet suggest that structure–function maps still require more precise characterizations. Given these relationships, we find that OCT data can predict glaucoma stage.
Conclusion: ganglion cell complex and RNFL thickness measurements are highlighted as the most promising candidate metrics for glaucoma detection and monitoring.
Text
s41433-020-0989-7
- Version of Record
More information
Accepted/In Press date: 18 May 2020
e-pub ahead of print date: 1 June 2020
Published date: March 2021
Additional Information:
Funding Information:
Acknowledgements GM was supported by a Marie-Skłodowska-Curie Actions Individual Fellowship (H2020-MSCA-IF-2017: ‘Visual-Grasping’ Project ID: 793660). This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018-2022 (legge 232 del 2016).
Publisher Copyright:
© 2020, The Author(s).
Identifiers
Local EPrints ID: 485086
URI: http://eprints.soton.ac.uk/id/eprint/485086
ISSN: 0950-222X
PURE UUID: be40706f-babe-4f05-a248-327ee24f47f1
Catalogue record
Date deposited: 29 Nov 2023 17:34
Last modified: 18 Mar 2024 04:11
Export record
Altmetrics
Contributors
Author:
Paola Cirafici
Author:
Guido Maiello
Author:
Chiara Ancona
Author:
Alessandro Masala
Author:
Carlo Enrico Traverso
Author:
Michele Iester
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics