Systematic review and meta-analysis of the association between maternal smoking in pregnancy and childhood overweight and obesity
Systematic review and meta-analysis of the association between maternal smoking in pregnancy and childhood overweight and obesity
Background: by 2020, it is predicted that 60 million children worldwide will be overweight. Maternal smoking in pregnancy has been suggested as a contributing factor. Our objective was to systematically review studies on this, thereby expanding the evidence base for this association.
Methods: systematic review with meta-analysis, Prospero Registration number CRD42012002859. We searched PubMed, Embase, Global Health, Web of Science and the Grey literature. We included prevalence, cohort and cross-sectional studies involving full-term, singleton pregnancies. Published and unpublished studies through to 1 January 2015 in all languages, demonstrating an objective overweight outcome up until 18 years of age and data presented as an OR, were included. Quality assessment was undertaken using an adaption of the Newcastle-Ottawa scale. Statistical analysis was performed using Review Manager V.5.3.
Findings: the meta-analysis included 39 studies of 236 687 children from Europe, Australia, North America and South America and Asia. Maternal smoking in pregnancy ranged from 5.5% to 38.7%, with the prevalence of overweight from 6.3% to 32.1% and obesity from 2.6% to 17%. Pooled adjusted ORs demonstrated an elevated odds of maternal smoking in pregnancy for childhood overweight (OR 1.37, 95% CI 1.28 to 1.46, I2 45%) and childhood obesity (OR 1.55, 95% CI 1.40 to 1.73, I2 24%).
Interpretation: our results demonstrate an association between maternal prenatal smoking and childhood overweight. This contributes to the growing evidence for the aetiology of childhood overweight, providing important information for policymakers and health professionals alike in planning cessation programmes or antismoking interventions for pregnant female smokers.
Child, Female, Humans, Mothers, Overweight/epidemiology, Pediatric Obesity/epidemiology, Pregnancy, Prenatal Exposure Delayed Effects, Prevalence, Risk Factors, Smoking/epidemiology
162-173
Rayfield, Sarah
f7c05f9c-91dc-4e0a-b7a2-41c905270ab3
Plugge, Emma
b64d2086-6cf2-4fae-98bf-6aafa3115b35
10 January 2017
Rayfield, Sarah
f7c05f9c-91dc-4e0a-b7a2-41c905270ab3
Plugge, Emma
b64d2086-6cf2-4fae-98bf-6aafa3115b35
Rayfield, Sarah and Plugge, Emma
(2017)
Systematic review and meta-analysis of the association between maternal smoking in pregnancy and childhood overweight and obesity.
Journal of Epidemiology and Community Health, 71 (2), .
(doi:10.1136/jech-2016-207376).
Abstract
Background: by 2020, it is predicted that 60 million children worldwide will be overweight. Maternal smoking in pregnancy has been suggested as a contributing factor. Our objective was to systematically review studies on this, thereby expanding the evidence base for this association.
Methods: systematic review with meta-analysis, Prospero Registration number CRD42012002859. We searched PubMed, Embase, Global Health, Web of Science and the Grey literature. We included prevalence, cohort and cross-sectional studies involving full-term, singleton pregnancies. Published and unpublished studies through to 1 January 2015 in all languages, demonstrating an objective overweight outcome up until 18 years of age and data presented as an OR, were included. Quality assessment was undertaken using an adaption of the Newcastle-Ottawa scale. Statistical analysis was performed using Review Manager V.5.3.
Findings: the meta-analysis included 39 studies of 236 687 children from Europe, Australia, North America and South America and Asia. Maternal smoking in pregnancy ranged from 5.5% to 38.7%, with the prevalence of overweight from 6.3% to 32.1% and obesity from 2.6% to 17%. Pooled adjusted ORs demonstrated an elevated odds of maternal smoking in pregnancy for childhood overweight (OR 1.37, 95% CI 1.28 to 1.46, I2 45%) and childhood obesity (OR 1.55, 95% CI 1.40 to 1.73, I2 24%).
Interpretation: our results demonstrate an association between maternal prenatal smoking and childhood overweight. This contributes to the growing evidence for the aetiology of childhood overweight, providing important information for policymakers and health professionals alike in planning cessation programmes or antismoking interventions for pregnant female smokers.
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More information
Accepted/In Press date: 11 July 2016
e-pub ahead of print date: 1 August 2016
Published date: 10 January 2017
Keywords:
Child, Female, Humans, Mothers, Overweight/epidemiology, Pediatric Obesity/epidemiology, Pregnancy, Prenatal Exposure Delayed Effects, Prevalence, Risk Factors, Smoking/epidemiology
Identifiers
Local EPrints ID: 485238
URI: http://eprints.soton.ac.uk/id/eprint/485238
ISSN: 0143-005X
PURE UUID: 2ba8ed5f-9eec-44d5-9790-722916a00810
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Date deposited: 01 Dec 2023 17:45
Last modified: 11 Jul 2024 02:06
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Author:
Sarah Rayfield
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