The University of Southampton
University of Southampton Institutional Repository

Adult mesenchymal stem cells and impaction grafting – a new clinical paradigm shift

Bolland, B.J.R.F, Tilley, S., New, A.M.R., Dunlop, D.G. and Oreffo, R.O.C. (2007) Adult mesenchymal stem cells and impaction grafting – a new clinical paradigm shift Expert Review of Medical Devices, 4, (3), pp. 393-404. (doi:10.1586/17434440.4.3.393).

Record type: Article

Abstract

The demographic challenges of an increasingly aging population emphasize the need for innovative approaches to skeletal reconstruction to augment and repair skeletal tissue lost as a consequence of implant loosening, trauma, degeneration or in situations involving revision surgery requiring bone stock. These clinical imperatives to augment skeletal tissue loss have brought mesenchymal stem cells to the fore in combination with the emerging discipline of tissue engineering. To date, impaction bone grafting for revision hip surgery is a recognized technique to reconstitute bone utilizing morselized allograft to provide a good mechanical scaffold, although with little osteoinductive biological potential. This review details laboratory and clinical examples of a paradigm shift in the application of mesenchymal stem cells with allograft to produce a living composite using the principles of tissue engineering. This step change creates a composite that offers a biological and mechanical advantage over the current gold standard of allograft alone. This translation of tissue engineering concepts into clinical practice offers enormous input into the field of bone regeneration and has implications for translation and future change in skeletal orthopedic practice in an increasingly aging population.

Full text not available from this repository.

More information

Published date: May 2007
Keywords: stem cells, tissue engineering, bone graft

Identifiers

Local EPrints ID: 48527
URI: http://eprints.soton.ac.uk/id/eprint/48527
ISSN: 1743-4440
PURE UUID: 4e146774-5ecf-4de2-aa3a-5e2c014cb7c4
ORCID for R.O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 01 Oct 2007
Last modified: 17 Jul 2017 14:59

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×