Impact of age on the short and long term outcomes following pancreaticodoudenectomy

Shamali, A., Jaber, B., Rawashdeh, M., Smith, R., Hamady, Z. and Abu Hilal, M. (2016) Impact of age on the short and long term outcomes following pancreaticodoudenectomy. HPB, 18 (Supplement 1), e425-e425. (doi:10.1016/j.hpb.2016.03.112).

Abstract

Background: geriatric population is rapidly growing. Short and long-term survival following elective surgery in elderly patients is not clear.

Methods: demography, operative and outcomes data were studied from a prospectively database undergoing pancreatico-duodenectomy (PD).

Patients were divided into two groups according to the age: Age <75 (Group A), Age ≥75 years (Group B).

Results: 444 patients were selected, there were 354 patients in group A and 90 patients in group B. Group B had more patients affected by heart disease compared to group A (p = 0.018). The two groups were similar in American Society of Anaesthesiology (ASA) score.

Overall complication was similar in the two groups. However, post-operative cardiac events and perioperative mortality were significantly higher in the elderly group (p = 0.021 and 0.011 respectively). Hospital stay length was higher in the elderly group, 12.5 compared to 15.2 days (p = 0.021). On multivariate analysis ASA score 3 and not age was found to be an independent predictive factor for perioperative mortality (P = 0.04 HR = 4.327 95% CI = 1.083–18.033). The pathological finding was pancreatic ductal adenocarcinoma (PDAC) in 161 patients (45.5%) of group A and 35 patients (38.9%) of group B (P = 0.268). Interestingly, median survival was 23 months in group A compared to 18 months in group B (p = 0.1).

Conclusion: age is not a limiting factor in patients undergoing PD however careful assessment is needed in elderly patients especially when age is associated with serious co-morbidities. The age does not appear to impact survival in patient undergoing a PD for PDAC.

This record has no associated files available for download.

Contributors

Author: Z. Hamady

Download statistics