Transgenerational and early-life nutrition, epigenetics, and prevention of obesity.
Transgenerational and early-life nutrition, epigenetics, and prevention of obesity.
Childhood obesity and associated noncommunicable diseases (NCDs) have increased at alarming rates, such that NCDs now account for 60% of deaths globally. Preventing obesity requires the identification of the underlying risk factors and the mediating molecular and physiological mechanisms. There is now substantial observational and experimental evidence indicating that transgenerational maternal and paternal nutritional exposures modulate epigenetic processes, which lead to phenotypic alterations and influence the later risk of obesity and other NCDs. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. Such epigenetic changes are induced during development function at the level of individual Cytosine-phosphate-Guanine (CpG) dinucleotides in both gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later obesity and other NCDs and aid identification of preventive, early mitigation and novel therapeutic strategies.
Epigenetics, Nutrition, Obesity
459-490
El-Heis, Sarah
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Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Tint, Mya Thway
02d6a006-3b94-4328-b3c3-147a618d66c3
Eriksson, Johan G.
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Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
20 October 2023
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Burton, Mark
250319ad-90dc-4651-b118-d5dbe5eaafa6
Tint, Mya Thway
02d6a006-3b94-4328-b3c3-147a618d66c3
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Lillycrop, Karen A.
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
El-Heis, Sarah, Burton, Mark, Tint, Mya Thway, Eriksson, Johan G., Lillycrop, Karen A. and Godfrey, Keith M.
(2023)
Transgenerational and early-life nutrition, epigenetics, and prevention of obesity.
In,
Tollefsbol, Trygve
(ed.)
Epigenetics in Human Disease, Third Edition: A Volume In Translational Epigenetics.
3 ed.
Academic Press, .
(doi:10.1016/B978-0-443-18661-5.00013-0).
Record type:
Book Section
Abstract
Childhood obesity and associated noncommunicable diseases (NCDs) have increased at alarming rates, such that NCDs now account for 60% of deaths globally. Preventing obesity requires the identification of the underlying risk factors and the mediating molecular and physiological mechanisms. There is now substantial observational and experimental evidence indicating that transgenerational maternal and paternal nutritional exposures modulate epigenetic processes, which lead to phenotypic alterations and influence the later risk of obesity and other NCDs. The epigenetic processes involved include DNA methylation, covalent modifications of histones, and noncoding RNAs. Such epigenetic changes are induced during development function at the level of individual Cytosine-phosphate-Guanine (CpG) dinucleotides in both gene promoter and intergenic regions. Elucidation of these epigenetic processes may permit perinatal identification of individuals most at risk of later obesity and other NCDs and aid identification of preventive, early mitigation and novel therapeutic strategies.
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e-pub ahead of print date: 20 October 2023
Published date: 20 October 2023
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© 2024 Elsevier Inc. All rights reserved.
Keywords:
Epigenetics, Nutrition, Obesity
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Local EPrints ID: 485357
URI: http://eprints.soton.ac.uk/id/eprint/485357
PURE UUID: 5fb4cfed-b57e-4f93-b064-2994a198b168
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Date deposited: 05 Dec 2023 17:35
Last modified: 18 Mar 2024 03:31
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Contributors
Author:
Sarah El-Heis
Author:
Mya Thway Tint
Author:
Johan G. Eriksson
Editor:
Trygve Tollefsbol
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