Severe parainfluenza viral infection-a retrospective study of adult intensive care patients
Severe parainfluenza viral infection-a retrospective study of adult intensive care patients
There is little known about parainfluenza virus (PIV) infection in adult intensive care unit (ICU) patients. Here, we aim to describe the characteristics, clinical course and outcomes of PIV infection in adults requiring intensive care. In this retrospective study of consecutive patients admitted to our ICU with confirmed PIV infection over a 7-year period, we report the patient characteristics, laboratory tests and prognostic scores on ICU admission. The main outcomes reported are 30-day mortality and organ support required. We included 50 patients (52% male, mean age 67.6 years). The mean PaO2/FiO2 and neutrophil/lymphocyte ratios on ICU admission were 198 ± 82 mmHg and 15.7 ± 12.5. Overall, 98% of patients required respiratory support and 24% required cardiovascular support. The median length of ICU stay was 5.9 days (IQR 3.7-9.1) with a 30-day mortality of 40%. In conclusion, PIV infection in adult ICU patients is associated with significant mortality and morbidity. There were significant differences between patients who presented with primary hypoxemic respiratory failure and hypercapnic respiratory failure.
intensive care, parainfluenza, pneumonia, respiratory failure, viral
Watson, Adam
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Beecham, Ryan
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Grocott, Michael P.W.
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Saeed, Kordo
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Dushianthan, Ahilanandan
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November 2023
Watson, Adam
40839854-70ee-4fd0-a871-2a565fc328a0
Beecham, Ryan
f930648f-5bcb-4c56-ae34-61db6d54b251
Grocott, Michael P.W.
1e87b741-513e-4a22-be13-0f7bb344e8c2
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751
Watson, Adam, Beecham, Ryan, Grocott, Michael P.W., Saeed, Kordo and Dushianthan, Ahilanandan
(2023)
Severe parainfluenza viral infection-a retrospective study of adult intensive care patients.
Journal of Clinical Medicine, 12 (22), [7106].
(doi:10.3390/jcm12227106).
Abstract
There is little known about parainfluenza virus (PIV) infection in adult intensive care unit (ICU) patients. Here, we aim to describe the characteristics, clinical course and outcomes of PIV infection in adults requiring intensive care. In this retrospective study of consecutive patients admitted to our ICU with confirmed PIV infection over a 7-year period, we report the patient characteristics, laboratory tests and prognostic scores on ICU admission. The main outcomes reported are 30-day mortality and organ support required. We included 50 patients (52% male, mean age 67.6 years). The mean PaO2/FiO2 and neutrophil/lymphocyte ratios on ICU admission were 198 ± 82 mmHg and 15.7 ± 12.5. Overall, 98% of patients required respiratory support and 24% required cardiovascular support. The median length of ICU stay was 5.9 days (IQR 3.7-9.1) with a 30-day mortality of 40%. In conclusion, PIV infection in adult ICU patients is associated with significant mortality and morbidity. There were significant differences between patients who presented with primary hypoxemic respiratory failure and hypercapnic respiratory failure.
Text
jcm-12-07106
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More information
Accepted/In Press date: 13 November 2023
e-pub ahead of print date: 15 November 2023
Published date: November 2023
Additional Information:
Funding Information:
In this retrospective study, we included consecutive adults with PIV infection requiring ICU admission in a large tertiary hospital in the south of England. The study data were collected for the period between 1 January 2016 and 30 June 2023. We excluded patients with incomplete or unretrievable patient records. This study was sponsored by the University Hospital Southampton NHS Foundation Trust (RHM CRI 0370) and ethical approval was obtained from the NHS Health Research Authority (IRAS 232922). Consent was waived due to the retrospective observational nature of this study. This study is compliant with local ethical standards and no identifiable patient data are presented here. This manuscript complies with STROBE guidelines [].
Funding Information:
A.W. is partially funded by the NIHR Academic Foundation Program. This research received no other external funding.
Publisher Copyright:
© 2023 by the authors.
Keywords:
intensive care, parainfluenza, pneumonia, respiratory failure, viral
Identifiers
Local EPrints ID: 485406
URI: http://eprints.soton.ac.uk/id/eprint/485406
ISSN: 2077-0383
PURE UUID: 9fb7995d-8d74-4686-a3ef-17936438189e
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Date deposited: 06 Dec 2023 17:32
Last modified: 06 Jun 2024 02:06
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Contributors
Author:
Adam Watson
Author:
Ryan Beecham
Author:
Kordo Saeed
Author:
Ahilanandan Dushianthan
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