Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis
Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis
Purpose: chronic hepatitis C infection and its treatment can considerably affect patients' health-related quality-of-life (HRQoL). This study aimed to identify and summarise the current evidence base for health state utility values (HSUVs) in patients with chronic hepatitis C infection, generated using the EuroQol 5-dimensions (EQ-5D) questionnaire.
Methods: MEDLINE, Embase, the Cochrane Library and EconLit were searched from database inception through 31 August 2017. Eligible studies reported HSUVs elicited using the EQ-5D questionnaire in adults with chronic hepatitis C infection. Study quality and risk of bias were assessed.
Results: of 1480 records identified, 26 studies were included. The most commonly defined health states described different stages of chronic hepatitis C infection and specific liver-related disease states, including METAVIR score, compensated and decompensated cirrhosis, hepatocellular carcinoma and liver transplantation. Patients with higher METAVIR scores tended to have lower EQ-5D scores compared to patients with lower METAVIR scores. Patients that achieved sustained virologic responses tended to have higher EQ-5D scores compared to those that did not. A meta-analysis conducted on three studies confirmed that patients with decompensated cirrhosis have significantly lower HSUVs than patients with compensated cirrhosis [mean difference - 0.11 (95% CI - 0.19 to - 0.04)], implying worse HRQoL. However, there was not sufficient evidence to compare how different treatments for chronic hepatitis C infection affect EQ-5D scores.
Conclusions: this study provides a summary of EQ-5D HSUVs for patients with chronic hepatitis C infection, and demonstrates that clinically important disease stages associated with treatment decisions are associated with differences in HRQoL.
Female, Hepatitis C, Chronic/pathology, Humans, Male, Middle Aged, Quality of Life/psychology, Surveys and Questionnaires
297-319
Buchanan-Hughes, A.M.
d7321ba9-7896-433f-b4ac-0724f499c47f
Buti, M.
e3b494d0-3bd7-46ab-a822-bd9ae4eb50e1
Hanman, K.
2b050378-544c-4a7d-9e7e-29c025a810ee
Langford, B.
05dd6187-b543-4e3b-b87d-2649290c4911
Wright, M.
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Eddowes, L.A.
f122b7f0-f7cb-4b05-9e81-a4257e4cf586
17 September 2018
Buchanan-Hughes, A.M.
d7321ba9-7896-433f-b4ac-0724f499c47f
Buti, M.
e3b494d0-3bd7-46ab-a822-bd9ae4eb50e1
Hanman, K.
2b050378-544c-4a7d-9e7e-29c025a810ee
Langford, B.
05dd6187-b543-4e3b-b87d-2649290c4911
Wright, M.
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Eddowes, L.A.
f122b7f0-f7cb-4b05-9e81-a4257e4cf586
Buchanan-Hughes, A.M., Buti, M., Hanman, K., Langford, B., Wright, M. and Eddowes, L.A.
(2018)
Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis.
Quality of Life Research, 28 (2), .
(doi:10.1007/s11136-018-1992-3).
Abstract
Purpose: chronic hepatitis C infection and its treatment can considerably affect patients' health-related quality-of-life (HRQoL). This study aimed to identify and summarise the current evidence base for health state utility values (HSUVs) in patients with chronic hepatitis C infection, generated using the EuroQol 5-dimensions (EQ-5D) questionnaire.
Methods: MEDLINE, Embase, the Cochrane Library and EconLit were searched from database inception through 31 August 2017. Eligible studies reported HSUVs elicited using the EQ-5D questionnaire in adults with chronic hepatitis C infection. Study quality and risk of bias were assessed.
Results: of 1480 records identified, 26 studies were included. The most commonly defined health states described different stages of chronic hepatitis C infection and specific liver-related disease states, including METAVIR score, compensated and decompensated cirrhosis, hepatocellular carcinoma and liver transplantation. Patients with higher METAVIR scores tended to have lower EQ-5D scores compared to patients with lower METAVIR scores. Patients that achieved sustained virologic responses tended to have higher EQ-5D scores compared to those that did not. A meta-analysis conducted on three studies confirmed that patients with decompensated cirrhosis have significantly lower HSUVs than patients with compensated cirrhosis [mean difference - 0.11 (95% CI - 0.19 to - 0.04)], implying worse HRQoL. However, there was not sufficient evidence to compare how different treatments for chronic hepatitis C infection affect EQ-5D scores.
Conclusions: this study provides a summary of EQ-5D HSUVs for patients with chronic hepatitis C infection, and demonstrates that clinically important disease stages associated with treatment decisions are associated with differences in HRQoL.
This record has no associated files available for download.
More information
Accepted/In Press date: 31 August 2018
Published date: 17 September 2018
Keywords:
Female, Hepatitis C, Chronic/pathology, Humans, Male, Middle Aged, Quality of Life/psychology, Surveys and Questionnaires
Identifiers
Local EPrints ID: 485435
URI: http://eprints.soton.ac.uk/id/eprint/485435
ISSN: 0962-9343
PURE UUID: ef6b3a31-5c03-48e5-b606-7d867d8bddf7
Catalogue record
Date deposited: 06 Dec 2023 17:42
Last modified: 17 Mar 2024 02:14
Export record
Altmetrics
Contributors
Author:
A.M. Buchanan-Hughes
Author:
M. Buti
Author:
K. Hanman
Author:
B. Langford
Author:
M. Wright
Author:
L.A. Eddowes
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics