Effect of Roux-en-Y gastric bypass on circulating oxylipin profile in women with obesity and type 2 diabetes
Effect of Roux-en-Y gastric bypass on circulating oxylipin profile in women with obesity and type 2 diabetes
Background & Aims: chronic inflammation associated with obesity directly contributes to metabolic comorbidities, including type 2 diabetes (T2D). Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for obesity-associated T2D. We investigated the effect of RYGB on the circulating profile of oxylipins derived from arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids as a potential mechanism underlying the metabolic benefits of the surgery.
Methods: plasma samples were collected from 28 women with obesity and T2D before and 3 months after RYGB. Circulating levels of oxylipins and their precursors, along with biochemical markers of glucose homeostasis, were evaluated using untargeted mass spectrometry and routine biochemical techniques, respectively.
Results: no significant changes were observed in the levels of oxylipins derived from EPA and DHA. However, there was an increase in ARA and its derived oxylipins, TXB2 (an inert derivative of TXA2) and PGD2 (Wilcoxon, p ≤ 0.05). Positive correlations were observed between hemoglobin A1c levels and TXB2 as well as ARA levels (Spearman, p ≤ 0.05).
Conclusions: our data suggest that the anti-inflammatory oxylipins derived from EPA and DHA may not be involved in the metabolic benefits associated with RYGB. However, the findings indicate that the pro-inflammatory oxylipin TXA2 and its precursor ARA may negatively impact glucose homeostasis both before and after RYGB.
Fatty acids, Gastric bypass, Inflammati, Obesity, Oxylipins
Cavalari Mancuzo, Daiane
c81d317f-6f99-42cb-a23e-3addcddfb9e7
Machado, Natasha Mendonça
2a677514-f855-4f1f-b1fa-80830fee5773
Teppedino, Juliana
74668651-5206-475a-8d47-3720797b3dec
Santander, Lucas
bfec547e-31a2-438f-bf02-2dc530e428d5
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Linetzky Waitzberg, Dan
afb6b437-3422-48aa-ab64-1c2b99d88d83
Torrinhas, Raquel Susana
c9d0ad72-ef69-437e-bcb4-4b531120f048
January 2024
Cavalari Mancuzo, Daiane
c81d317f-6f99-42cb-a23e-3addcddfb9e7
Machado, Natasha Mendonça
2a677514-f855-4f1f-b1fa-80830fee5773
Teppedino, Juliana
74668651-5206-475a-8d47-3720797b3dec
Santander, Lucas
bfec547e-31a2-438f-bf02-2dc530e428d5
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Linetzky Waitzberg, Dan
afb6b437-3422-48aa-ab64-1c2b99d88d83
Torrinhas, Raquel Susana
c9d0ad72-ef69-437e-bcb4-4b531120f048
Cavalari Mancuzo, Daiane, Machado, Natasha Mendonça, Teppedino, Juliana, Santander, Lucas, Calder, Philip, Linetzky Waitzberg, Dan and Torrinhas, Raquel Susana
(2024)
Effect of Roux-en-Y gastric bypass on circulating oxylipin profile in women with obesity and type 2 diabetes.
Prostaglandins, Leukotrienes and Essential Fatty Acids, 200, [102605].
(doi:10.1016/j.plefa.2023.102605).
Abstract
Background & Aims: chronic inflammation associated with obesity directly contributes to metabolic comorbidities, including type 2 diabetes (T2D). Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for obesity-associated T2D. We investigated the effect of RYGB on the circulating profile of oxylipins derived from arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids as a potential mechanism underlying the metabolic benefits of the surgery.
Methods: plasma samples were collected from 28 women with obesity and T2D before and 3 months after RYGB. Circulating levels of oxylipins and their precursors, along with biochemical markers of glucose homeostasis, were evaluated using untargeted mass spectrometry and routine biochemical techniques, respectively.
Results: no significant changes were observed in the levels of oxylipins derived from EPA and DHA. However, there was an increase in ARA and its derived oxylipins, TXB2 (an inert derivative of TXA2) and PGD2 (Wilcoxon, p ≤ 0.05). Positive correlations were observed between hemoglobin A1c levels and TXB2 as well as ARA levels (Spearman, p ≤ 0.05).
Conclusions: our data suggest that the anti-inflammatory oxylipins derived from EPA and DHA may not be involved in the metabolic benefits associated with RYGB. However, the findings indicate that the pro-inflammatory oxylipin TXA2 and its precursor ARA may negatively impact glucose homeostasis both before and after RYGB.
Restricted to Repository staff only until 12 December 2024.
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Accepted/In Press date: 12 December 2023
e-pub ahead of print date: 13 December 2023
Published date: January 2024
Additional Information:
Does not comply with NIHR OA policy due to embargo on AAM. No RRS found in AAM.
Publisher Copyright:
© 2023 Elsevier Ltd
Keywords:
Fatty acids, Gastric bypass, Inflammati, Obesity, Oxylipins
Identifiers
Local EPrints ID: 485690
URI: http://eprints.soton.ac.uk/id/eprint/485690
ISSN: 0952-3278
PURE UUID: 1b207c88-42ea-42bd-a288-c3fec418a28b
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Date deposited: 14 Dec 2023 17:37
Last modified: 18 Mar 2024 02:41
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Contributors
Author:
Daiane Cavalari Mancuzo
Author:
Natasha Mendonça Machado
Author:
Juliana Teppedino
Author:
Lucas Santander
Author:
Dan Linetzky Waitzberg
Author:
Raquel Susana Torrinhas
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