Consequences of perinatal vitamin D deficiency on later bone health
Consequences of perinatal vitamin D deficiency on later bone health
Vitamin D has important roles in calcium metabolism and in the prevention of rickets and osteomalacia. There is also increasing evidence to suggest a role for vitamin D in developmental programming of bone and muscle; recently reported randomized controlled trials of pregnancy vitamin D supplementation have demonstrated positive effects on offspring bone mineral density in early childhood and elucidated potential epigenetic mechanisms underlying the observed relationships. The current evidence supports prevention of vitamin D deficiency in pregnancy, with further follow-up of participants of mother–offspring intervention studies required to demonstrate persistence of a beneficial effect of high-dose vitamin D through puberty to peak bone mass before routine high dose supplementation can be advised.
Bone mineral density, Osteoporosis, Pregnancy, Vitamin D
777-799
Moon, Rebecca J.
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Curtis, Elizabeth M.
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Cleal, Jane K.
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Dennison, Elaine M.
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Cooper, Cyrus
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Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
3 November 2023
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
Curtis, Elizabeth M.
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J., Curtis, Elizabeth M., Cleal, Jane K., Dennison, Elaine M., Cooper, Cyrus and Harvey, Nicholas C.
(2023)
Consequences of perinatal vitamin D deficiency on later bone health.
In,
Hewison, Martin, Bouillon, Roger, Giovannucci, Edward, Goltzman, David, Meyer, Mark and Welsh, JoEllen
(eds.)
Feldman and Pike's Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics.
5 ed.
Academic Press, .
(doi:10.1016/B978-0-323-91386-7.00037-4).
Record type:
Book Section
Abstract
Vitamin D has important roles in calcium metabolism and in the prevention of rickets and osteomalacia. There is also increasing evidence to suggest a role for vitamin D in developmental programming of bone and muscle; recently reported randomized controlled trials of pregnancy vitamin D supplementation have demonstrated positive effects on offspring bone mineral density in early childhood and elucidated potential epigenetic mechanisms underlying the observed relationships. The current evidence supports prevention of vitamin D deficiency in pregnancy, with further follow-up of participants of mother–offspring intervention studies required to demonstrate persistence of a beneficial effect of high-dose vitamin D through puberty to peak bone mass before routine high dose supplementation can be advised.
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e-pub ahead of print date: 3 November 2023
Published date: 3 November 2023
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Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.
Keywords:
Bone mineral density, Osteoporosis, Pregnancy, Vitamin D
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Local EPrints ID: 485899
URI: http://eprints.soton.ac.uk/id/eprint/485899
PURE UUID: dbf0b0be-1076-4eda-b9d3-8e8d47aba0b4
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Date deposited: 03 Jan 2024 23:59
Last modified: 18 Mar 2024 03:38
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Contributors
Author:
Rebecca J. Moon
Editor:
Martin Hewison
Editor:
Roger Bouillon
Editor:
Edward Giovannucci
Editor:
David Goltzman
Editor:
Mark Meyer
Editor:
JoEllen Welsh
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