Nano-enabled biomarker discovery and detection
Nano-enabled biomarker discovery and detection
The completion of the human genome project has led to intensified efforts toward comprehensive analysis of proteomes. New possibilities exist for efficient proteomic technologies. However, primary attention is given to the discovery of new predictive biomarker patterns. Understanding proteomes and, in particular, protein-mediated interactions underlying their complexity and diversity, is critical for the development of more reliable and robust diagnostic platforms, which are anticipated to enable personalized medicine. Of immediate relevance in this respect are those approaches that capitalize on the application of nanotechnology, which is seen as a powerful tool for the diagnosis of early-stage diseases. Here we highlight the current state of the field exemplified by recent nano-enabled technologies for biomarker discovery.
amyloid-b, biomarker, biomarker harvesting, cancer, integrins, nanoparticles, neurodegenerative disease, proteomics
387-396
Rakowska, Paulina D.
73bf2145-e2fa-46ee-9ad9-f74c80d5a369
Ryadnov, Maxim G.
0621e854-f160-40c6-ab8d-1afbf48089fd
Rakowska, Paulina D.
73bf2145-e2fa-46ee-9ad9-f74c80d5a369
Ryadnov, Maxim G.
0621e854-f160-40c6-ab8d-1afbf48089fd
Rakowska, Paulina D. and Ryadnov, Maxim G.
(2011)
Nano-enabled biomarker discovery and detection.
Biomarkers in Medicine, 5 (3), .
(doi:10.2217/bmm.11.26).
Abstract
The completion of the human genome project has led to intensified efforts toward comprehensive analysis of proteomes. New possibilities exist for efficient proteomic technologies. However, primary attention is given to the discovery of new predictive biomarker patterns. Understanding proteomes and, in particular, protein-mediated interactions underlying their complexity and diversity, is critical for the development of more reliable and robust diagnostic platforms, which are anticipated to enable personalized medicine. Of immediate relevance in this respect are those approaches that capitalize on the application of nanotechnology, which is seen as a powerful tool for the diagnosis of early-stage diseases. Here we highlight the current state of the field exemplified by recent nano-enabled technologies for biomarker discovery.
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e-pub ahead of print date: 9 June 2011
Keywords:
amyloid-b, biomarker, biomarker harvesting, cancer, integrins, nanoparticles, neurodegenerative disease, proteomics
Identifiers
Local EPrints ID: 485936
URI: http://eprints.soton.ac.uk/id/eprint/485936
ISSN: 1752-0363
PURE UUID: ee022f97-449a-425e-ab22-c49265891c45
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Date deposited: 04 Jan 2024 04:57
Last modified: 18 Mar 2024 03:59
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Author:
Maxim G. Ryadnov
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