Embracing ethical research: implementing the 3R principles into fracture healing research for sustainable scientific progress
Embracing ethical research: implementing the 3R principles into fracture healing research for sustainable scientific progress
As scientific advancements continue to reshape the world, it becomes increasingly crucial to uphold ethical standards and minimize the potentially adverse impact of research activities. In this context, the implementation of the 3R principles-Replacement, Reduction, and Refinement-has emerged as a prominent framework for promoting ethical research practices in the use of animals. This article aims to explore recent advances in integrating the 3R principles into fracture healing research, highlighting their potential to enhance animal welfare, scientific validity, and societal trust. The review focuses on in vitro, in silico, ex vivo, and refined in vivo methods, which have the potential to replace, reduce, and refine animal experiments in musculoskeletal, bone, and fracture healing research. Here, we review material that was presented at the workshop "Implementing 3R Principles into Fracture Healing Research" at the 2023 Orthopedic Research Society (ORS) Annual Meeting in Dallas, Texas.
3R principles and ethics, animal models, bone regeneration, fracture healing
Anup, Amritha
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Dieterich, Sandra
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Oreffo, Richard O.C.
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Dailey, Hannah L.
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Lang, Annemarie
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Haffner-Luntzer, Melanie
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Hixon, Katherine R.
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Anup, Amritha
3d5b0c1d-2bd7-48fc-a0d5-20140e0e614b
Dieterich, Sandra
ddc259db-fd99-4163-ae3a-e30426090717
Oreffo, Richard O.C.
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Dailey, Hannah L.
21ddbdcc-38b9-438c-9c9b-97f43f98e189
Lang, Annemarie
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Haffner-Luntzer, Melanie
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Hixon, Katherine R.
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Anup, Amritha, Dieterich, Sandra, Oreffo, Richard O.C., Dailey, Hannah L., Lang, Annemarie, Haffner-Luntzer, Melanie and Hixon, Katherine R.
(2023)
Embracing ethical research: implementing the 3R principles into fracture healing research for sustainable scientific progress.
Journal of Orthopaedic Research.
(doi:10.1002/jor.25741).
Abstract
As scientific advancements continue to reshape the world, it becomes increasingly crucial to uphold ethical standards and minimize the potentially adverse impact of research activities. In this context, the implementation of the 3R principles-Replacement, Reduction, and Refinement-has emerged as a prominent framework for promoting ethical research practices in the use of animals. This article aims to explore recent advances in integrating the 3R principles into fracture healing research, highlighting their potential to enhance animal welfare, scientific validity, and societal trust. The review focuses on in vitro, in silico, ex vivo, and refined in vivo methods, which have the potential to replace, reduce, and refine animal experiments in musculoskeletal, bone, and fracture healing research. Here, we review material that was presented at the workshop "Implementing 3R Principles into Fracture Healing Research" at the 2023 Orthopedic Research Society (ORS) Annual Meeting in Dallas, Texas.
Text
3Rs paper accepted version
- Accepted Manuscript
More information
Accepted/In Press date: 14 November 2023
e-pub ahead of print date: 20 December 2023
Additional Information:
Funding Information:
We thank Prof. Oreffo, Prof. Dailey, and Dr. Lang for their great talks about the presented topics at the ORS 2023 Annual Meeting. Richard O. C. Oreffo is funded by grants from the UK Regenerative Medicine Platform Acellular Hub, SMART materials 3D architecture (MR/R015651/1) and the UK Regenerative Medicine Platform (MR/L012626/1 Southampton Imaging). Annemarie Lang receives a Marie Skłodowska‐Curie Postdoctoral Fellowship (MSCA‐PF‐2021‐GF; GA 101063997) funded by the European Union. Hannah L. Dailey discloses research grants from the National Science Foundation (CMMI‐1943287), Orthopaedic Trauma Association, and National Institutes of Health (1R21 R081435‐01) related to the subject matter of this review.
Publisher Copyright:
© 2023 Orthopaedic Research Society.
Keywords:
3R principles and ethics, animal models, bone regeneration, fracture healing
Identifiers
Local EPrints ID: 486088
URI: http://eprints.soton.ac.uk/id/eprint/486088
ISSN: 0736-0266
PURE UUID: 77403d65-dcc4-4f0d-abbf-94ec159a38f0
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Date deposited: 09 Jan 2024 17:33
Last modified: 20 Dec 2024 05:01
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Contributors
Author:
Amritha Anup
Author:
Sandra Dieterich
Author:
Hannah L. Dailey
Author:
Annemarie Lang
Author:
Melanie Haffner-Luntzer
Author:
Katherine R. Hixon
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