Vitamin D and the placenta
Vitamin D and the placenta
The physiological roles of vitamin D during pregnancy are diverse and complex with actions in the mother, placenta, and fetus affecting calcium homeostasis and cell proliferation as well as inflammation and immune function. It is necessary to distinguish the effects of vitamin D on the placenta and to recognize the placenta's role in determining vitamin D actions in the fetus. The current understanding of the physiology of vitamin D during pregnancy, specifically its interaction with the placenta will be discussed. We will also discuss the evidence base linking placental function and structure to fetal vitamin D supply and the mechanisms that could underlie this relationship and placental responses to maternal vitamin D levels, which could subsequently influence fetal development. Understanding the processes affecting these placental mechanisms is key to addressing clinical complications linked to impaired vitamin D status during pregnancy and designing effective interventions.
Fetal development, Fetal programming, Placenta, Placental function, Pregnancy, Vitamin D metabolism, Vitamin D transfer
761-776
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
3 November 2023
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cleal, Jane K., Lewis, Rohan M. and Harvey, Nicholas C.
(2023)
Vitamin D and the placenta.
In,
Hewison, Martin, Bouillon, Roger, Giovannucci, Edward, Goltzman, David, Meyer, Mark and Welsh, JoEllen
(eds.)
Feldman and Pike' s Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics.
5 ed.
Academic Press, .
(doi:10.1016/B978-0-323-91386-7.00034-9).
Record type:
Book Section
Abstract
The physiological roles of vitamin D during pregnancy are diverse and complex with actions in the mother, placenta, and fetus affecting calcium homeostasis and cell proliferation as well as inflammation and immune function. It is necessary to distinguish the effects of vitamin D on the placenta and to recognize the placenta's role in determining vitamin D actions in the fetus. The current understanding of the physiology of vitamin D during pregnancy, specifically its interaction with the placenta will be discussed. We will also discuss the evidence base linking placental function and structure to fetal vitamin D supply and the mechanisms that could underlie this relationship and placental responses to maternal vitamin D levels, which could subsequently influence fetal development. Understanding the processes affecting these placental mechanisms is key to addressing clinical complications linked to impaired vitamin D status during pregnancy and designing effective interventions.
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e-pub ahead of print date: 3 November 2023
Published date: 3 November 2023
Additional Information:
Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.
Keywords:
Fetal development, Fetal programming, Placenta, Placental function, Pregnancy, Vitamin D metabolism, Vitamin D transfer
Identifiers
Local EPrints ID: 486095
URI: http://eprints.soton.ac.uk/id/eprint/486095
PURE UUID: 25e3f472-0048-4071-abe3-6edb8dea240d
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Date deposited: 09 Jan 2024 17:41
Last modified: 18 Mar 2024 02:59
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Contributors
Editor:
Martin Hewison
Editor:
Roger Bouillon
Editor:
Edward Giovannucci
Editor:
David Goltzman
Editor:
Mark Meyer
Editor:
JoEllen Welsh
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