A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P
Li, Shaobo
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Spitz, Natalia
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Ghantous, Akram
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Kitaba, Negusse
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Rezwan, Faisal I.
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Arshad, S. Hasan
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Holloway, John W.
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9 January 2024
Li, Shaobo
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Spitz, Natalia
175f44ca-e303-42b1-9603-da7351ed3cb8
Ghantous, Akram
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Kitaba, Negusse
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Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Li, Shaobo, Spitz, Natalia and Ghantous, Akram
,
et al.
(2024)
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation.
Communications Biology, 7 (1), [66].
(doi:10.1038/s42003-023-05698-x).
Abstract
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P
Text
s42003-023-05698-x
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Accepted/In Press date: 12 December 2023
e-pub ahead of print date: 9 January 2024
Published date: 9 January 2024
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© 2024, The Author(s).
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Local EPrints ID: 486177
URI: http://eprints.soton.ac.uk/id/eprint/486177
ISSN: 2399-3642
PURE UUID: 56103e89-ea01-43a5-b0bc-2f1a4a51b510
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Date deposited: 12 Jan 2024 17:36
Last modified: 02 May 2024 01:50
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Author:
Shaobo Li
Author:
Natalia Spitz
Author:
Akram Ghantous
Author:
Faisal I. Rezwan
Corporate Author: et al.
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