Baseline and change in serum uric acid level over time and resolution of NAFLD in young adults: the Kangbuk Samsung Health Study
Baseline and change in serum uric acid level over time and resolution of NAFLD in young adults: the Kangbuk Samsung Health Study
Aims: to determine the association between: (i) baseline serum uric acid (SUA) level and (ii) SUA changes over time, and nonalcoholic fatty liver disease (NAFLD) resolution.
Materials and Methods: a retrospective cohort study, comprising 38 483 subjects aged <40 years with pre-existing NAFLD, was undertaken. The effects of SUA changes over time were studied in 25 266 subjects. Participants underwent a health examination between 2011 and 2019, and at least one follow-up liver ultrasonography scan up to December 2020. Exposures included baseline SUA level and SUA changes between baseline and subsequent visits, categorized into quintiles. The reference group was the third quintile (Q3) containing zero change. The primary endpoint was resolution of NAFLD.
Results: during a median follow-up of 4 years, low baseline SUA level and decreases in SUA levels over time were independently associated with NAFLD resolution (p for trend <0.001). Using SUA as a continuous variable, the likelihood of NAFLD resolution was increased by 10% and 13% in men and women, respectively, per 1-mg/dL decrease in SUA. In a time-dependent model with changes in SUA treated as a time-varying covariate, adjusted hazard ratios (95% confidence intervals) for NAFLD resolution comparing Q1 (highest decrease) and Q2 (slight decrease) to Q3 (reference) were 1.63 (1.49–1.78) and 1.23 (1.11–1.35) in men and 1.78 (1.49–2.12) and 1.18 (0.95–1.46) in women, respectively.
Conclusions: low baseline SUA levels and a decrease in SUA levels over time were both associated with NAFLD resolution in young adults.
changes in serum uric acid, cohort study, nonalcoholic fatty liver disease, serum uric acid, young adults
1644-1657
Cho, Yoosun
5c2c4bd7-8a0a-403e-8d90-6dc3bd513e7e
Chang, Yoosoo
d3071022-330c-49b9-a623-4f9a5604c4d8
Ryu, Seungho
dd2de92e-3cd7-4b2d-b044-14b8cbf705c5
Wild, Sarah H.
95d1d797-cc81-4872-9639-893351cb8864
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
1 May 2024
Cho, Yoosun
5c2c4bd7-8a0a-403e-8d90-6dc3bd513e7e
Chang, Yoosoo
d3071022-330c-49b9-a623-4f9a5604c4d8
Ryu, Seungho
dd2de92e-3cd7-4b2d-b044-14b8cbf705c5
Wild, Sarah H.
95d1d797-cc81-4872-9639-893351cb8864
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Cho, Yoosun, Chang, Yoosoo and Ryu, Seungho
,
et al.
(2024)
Baseline and change in serum uric acid level over time and resolution of NAFLD in young adults: the Kangbuk Samsung Health Study.
Diabetes, Obesity and Metabolism, 26 (5), .
(doi:10.1111/dom.15466).
Abstract
Aims: to determine the association between: (i) baseline serum uric acid (SUA) level and (ii) SUA changes over time, and nonalcoholic fatty liver disease (NAFLD) resolution.
Materials and Methods: a retrospective cohort study, comprising 38 483 subjects aged <40 years with pre-existing NAFLD, was undertaken. The effects of SUA changes over time were studied in 25 266 subjects. Participants underwent a health examination between 2011 and 2019, and at least one follow-up liver ultrasonography scan up to December 2020. Exposures included baseline SUA level and SUA changes between baseline and subsequent visits, categorized into quintiles. The reference group was the third quintile (Q3) containing zero change. The primary endpoint was resolution of NAFLD.
Results: during a median follow-up of 4 years, low baseline SUA level and decreases in SUA levels over time were independently associated with NAFLD resolution (p for trend <0.001). Using SUA as a continuous variable, the likelihood of NAFLD resolution was increased by 10% and 13% in men and women, respectively, per 1-mg/dL decrease in SUA. In a time-dependent model with changes in SUA treated as a time-varying covariate, adjusted hazard ratios (95% confidence intervals) for NAFLD resolution comparing Q1 (highest decrease) and Q2 (slight decrease) to Q3 (reference) were 1.63 (1.49–1.78) and 1.23 (1.11–1.35) in men and 1.78 (1.49–2.12) and 1.18 (0.95–1.46) in women, respectively.
Conclusions: low baseline SUA levels and a decrease in SUA levels over time were both associated with NAFLD resolution in young adults.
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More information
Accepted/In Press date: 9 January 2024
e-pub ahead of print date: 1 February 2024
Published date: 1 May 2024
Keywords:
changes in serum uric acid, cohort study, nonalcoholic fatty liver disease, serum uric acid, young adults
Identifiers
Local EPrints ID: 486178
URI: http://eprints.soton.ac.uk/id/eprint/486178
ISSN: 1462-8902
PURE UUID: 98f637e2-2c75-43b1-a2f0-1f26fee2ee55
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Date deposited: 12 Jan 2024 17:36
Last modified: 16 Apr 2024 01:36
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Contributors
Author:
Yoosun Cho
Author:
Yoosoo Chang
Author:
Seungho Ryu
Author:
Sarah H. Wild
Corporate Author: et al.
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