Cohort profile: post-hospitalisation COVID-19 (PHOSP-COVID) study
Cohort profile: post-hospitalisation COVID-19 (PHOSP-COVID) study
The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.
PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalization, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments and to serve as a platform to enable future studies, including clinical trials.
Data collected covered a wide range of physical measures, biological samples and patient-reported outcome measures (PROMs).
Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA; or in Tier 2 in which they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at 5 (range 2–7) months and 12 (range 10–14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.
All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.
In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.
Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals from https://www.phosp.org/data-sample-request/.
Elneima, Omer
f63465fa-6af2-4346-809d-248160659e7b
McAuley, Hamish J.C.
7c7abd53-d2be-45f8-bc82-a5bb727f5945
Leavy, Olivia C.
31fedd8a-9d66-42a3-bf92-0ea370a8aaee
Jones, Mark G.
a6fd492e-058e-4e84-a486-34c6035429c1
on Behalf of the PHOSP-COVID Collaborative Group
Elneima, Omer
f63465fa-6af2-4346-809d-248160659e7b
McAuley, Hamish J.C.
7c7abd53-d2be-45f8-bc82-a5bb727f5945
Leavy, Olivia C.
31fedd8a-9d66-42a3-bf92-0ea370a8aaee
Jones, Mark G.
a6fd492e-058e-4e84-a486-34c6035429c1
Elneima, Omer, McAuley, Hamish J.C. and Leavy, Olivia C.
,
et al. and on Behalf of the PHOSP-COVID Collaborative Group
(2023)
Cohort profile: post-hospitalisation COVID-19 (PHOSP-COVID) study.
International Journal of Epidemiology.
(doi:10.1093/ije/dyad165).
Abstract
The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.
PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalization, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments and to serve as a platform to enable future studies, including clinical trials.
Data collected covered a wide range of physical measures, biological samples and patient-reported outcome measures (PROMs).
Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA; or in Tier 2 in which they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at 5 (range 2–7) months and 12 (range 10–14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.
All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.
In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.
Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals from https://www.phosp.org/data-sample-request/.
Text
dyad165
- Version of Record
More information
Accepted/In Press date: 7 December 2023
e-pub ahead of print date: 18 December 2023
Additional Information:
For the purpose of open access, the author has applied a CC-BY public copyright licence to any author accepted manuscript version arising from this submission.
Identifiers
Local EPrints ID: 486270
URI: http://eprints.soton.ac.uk/id/eprint/486270
ISSN: 0300-5771
PURE UUID: 61f225db-eb05-42a9-be82-7af1cfce0156
Catalogue record
Date deposited: 16 Jan 2024 17:40
Last modified: 18 Mar 2024 03:07
Export record
Altmetrics
Contributors
Author:
Omer Elneima
Author:
Hamish J.C. McAuley
Author:
Olivia C. Leavy
Corporate Author: et al.
Corporate Author: on Behalf of the PHOSP-COVID Collaborative Group
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
