The University of Southampton
University of Southampton Institutional Repository

Biomarkers of inflammation increase with tau and neurodegeneration but not with Amyloid-β in a heterogenous clinical cohort

Biomarkers of inflammation increase with tau and neurodegeneration but not with Amyloid-β in a heterogenous clinical cohort
Biomarkers of inflammation increase with tau and neurodegeneration but not with Amyloid-β in a heterogenous clinical cohort
Background: neuroinflammation is an integral part of Alzheimer’s disease (AD) pathology. Inflammatory mediators can exacerbate the production of amyloid-β (Aβ), the propagation of tau pathology and neuronal loss.

Objective: to evaluate the relationship between inflammation markers and established markers of AD in a mixed memory clinic cohort.

Methods: 105 cerebrospinal fluid (CSF) samples from a clinical cohort under investigation for cognitive complaints were analyzed. Levels of Aβ42, total tau, and phosphorylated tau were measured as part of the clinical pathway. Analysis of inflammation markers in CSF samples was performed using multiplex immune assays. Participants were grouped according to their Aβ, tau, and neurodegeneration status and the Paris-Lille-Montpellier (PLM) scale was used to assess the likelihood of AD.

Results: from 102 inflammatory markers analyzed, 19 and 23 markers were significantly associated with CSF total tau and phosphorylated tau levels respectively (p 
Conclusion: CSF inflammation markers increase significantly with tau and neurodegeneration, but not with Aβ in this mixed memory clinic cohort. Thus, such markers could become useful for the clinical diagnosis of neurodegenerative disorders alongside the established Aβ and tau measures.
1387-2877
1303-1314
Michopoulou, Sofia
f21ba2a3-f5d3-4998-801f-1ae72ff5d92c
Prosser, Angus
de1efee5-67f5-478e-8cfa-12a8e78a68e5
Kipps, Christopher
e43be016-2dc2-45e6-9a02-ab2a0e0208d5
Dickson, John
627f7f54-97e9-4cc1-812c-728c3973265d
Guy, Matthew
473bbb88-641b-40a5-b22d-221bc048eeb5
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Michopoulou, Sofia
f21ba2a3-f5d3-4998-801f-1ae72ff5d92c
Prosser, Angus
de1efee5-67f5-478e-8cfa-12a8e78a68e5
Kipps, Christopher
e43be016-2dc2-45e6-9a02-ab2a0e0208d5
Dickson, John
627f7f54-97e9-4cc1-812c-728c3973265d
Guy, Matthew
473bbb88-641b-40a5-b22d-221bc048eeb5
Teeling, Jessica
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a

Michopoulou, Sofia, Prosser, Angus, Kipps, Christopher, Dickson, John, Guy, Matthew and Teeling, Jessica (2022) Biomarkers of inflammation increase with tau and neurodegeneration but not with Amyloid-β in a heterogenous clinical cohort. Journal of Alzheimer's Disease, 89 (4), 1303-1314. (doi:10.3233/JAD-220523).

Record type: Article

Abstract

Background: neuroinflammation is an integral part of Alzheimer’s disease (AD) pathology. Inflammatory mediators can exacerbate the production of amyloid-β (Aβ), the propagation of tau pathology and neuronal loss.

Objective: to evaluate the relationship between inflammation markers and established markers of AD in a mixed memory clinic cohort.

Methods: 105 cerebrospinal fluid (CSF) samples from a clinical cohort under investigation for cognitive complaints were analyzed. Levels of Aβ42, total tau, and phosphorylated tau were measured as part of the clinical pathway. Analysis of inflammation markers in CSF samples was performed using multiplex immune assays. Participants were grouped according to their Aβ, tau, and neurodegeneration status and the Paris-Lille-Montpellier (PLM) scale was used to assess the likelihood of AD.

Results: from 102 inflammatory markers analyzed, 19 and 23 markers were significantly associated with CSF total tau and phosphorylated tau levels respectively (p 
Conclusion: CSF inflammation markers increase significantly with tau and neurodegeneration, but not with Aβ in this mixed memory clinic cohort. Thus, such markers could become useful for the clinical diagnosis of neurodegenerative disorders alongside the established Aβ and tau measures.

Text
jad-89-jad220523 - Version of Record
Available under License Creative Commons Attribution.
Download (494kB)

More information

Accepted/In Press date: 25 July 2022
Published date: 11 October 2022

Identifiers

Local EPrints ID: 486299
URI: http://eprints.soton.ac.uk/id/eprint/486299
ISSN: 1387-2877
PURE UUID: 28a4734c-fc46-4ff2-bb75-76d00dca2279
ORCID for Angus Prosser: ORCID iD orcid.org/0000-0003-2705-1222
ORCID for Christopher Kipps: ORCID iD orcid.org/0000-0002-5205-9712
ORCID for Jessica Teeling: ORCID iD orcid.org/0000-0003-4004-7391

Catalogue record

Date deposited: 16 Jan 2024 17:53
Last modified: 28 May 2024 17:34

Export record

Altmetrics

Contributors

Author: Sofia Michopoulou
Author: Angus Prosser ORCID iD
Author: Christopher Kipps ORCID iD
Author: John Dickson
Author: Matthew Guy
Author: Jessica Teeling ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×