Long-term cardiovascular effects of medications for attention-deficit/hyperactivity disorder—balancing benefits and risks of treatment
Long-term cardiovascular effects of medications for attention-deficit/hyperactivity disorder—balancing benefits and risks of treatment
Will this medication have negative effects in the short and long term?
This is a very common question clinicians encounter when discussing the option of starting a pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), which includes stimulants (methylphenidate and amphetamines) and nonstimulants (eg, atomoxetine, clonidine, guanfacine, and viloxazine).1 Concerns about cardiovascular risk associated with ADHD medications, particularly stimulants, are among the most serious ones. Indeed, as stimulants are sympathomimetic agents with dopaminergic and noradrenergic effects, increased values of heart rate and blood pressure after treatment are plausible from a biological standpoint.1 In turn, over the long term, sustained increases in heart rate and blood pressure might result in left ventricular hypertrophy and an elevated risk of myocardial infarction.
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Fava, Cristiano
4e10c408-865c-4efa-8bde-1c8259e177cb
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Fava, Cristiano
4e10c408-865c-4efa-8bde-1c8259e177cb
Cortese, Samuele and Fava, Cristiano
(2023)
Long-term cardiovascular effects of medications for attention-deficit/hyperactivity disorder—balancing benefits and risks of treatment.
JAMA Psychiatry.
(doi:10.1001/jamapsychiatry.2023.4126).
Abstract
Will this medication have negative effects in the short and long term?
This is a very common question clinicians encounter when discussing the option of starting a pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), which includes stimulants (methylphenidate and amphetamines) and nonstimulants (eg, atomoxetine, clonidine, guanfacine, and viloxazine).1 Concerns about cardiovascular risk associated with ADHD medications, particularly stimulants, are among the most serious ones. Indeed, as stimulants are sympathomimetic agents with dopaminergic and noradrenergic effects, increased values of heart rate and blood pressure after treatment are plausible from a biological standpoint.1 In turn, over the long term, sustained increases in heart rate and blood pressure might result in left ventricular hypertrophy and an elevated risk of myocardial infarction.
Text
230930_EDITORIAL_JAMA_Psyc_SUBMITTED (1)
- Accepted Manuscript
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e-pub ahead of print date: 22 November 2023
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Local EPrints ID: 486419
URI: http://eprints.soton.ac.uk/id/eprint/486419
ISSN: 2168-6238
PURE UUID: 0c5c97ed-2c78-4abd-84ce-a9e416b5da69
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Date deposited: 22 Jan 2024 17:32
Last modified: 19 Jul 2024 01:47
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Author:
Cristiano Fava
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