Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study
Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study
Background Asthma-related burden remains poorly characterised in children in the UK. We quantified recent trends in asthma prevalence and burden in a UK population-based cohort (1-17-year-olds). Methods The Clinical Practice Research Datalink Aurum database (2008-2018) was used to assess annual asthma incidence and prevalence in 1-17-year-olds and preschool wheeze in 1-5-year-olds, stratified by sex and age. During the same period, annual asthma exacerbation rates were assessed in those with either a diagnosis of preschool wheeze or asthma. Results Annual asthma incidence rates decreased by 51% from 1403.4 (95% CI 1383.7 to 1423.2) in 2008 to 688.0 (95% CI 676.3 to 699.9) per 10 5 person-years (PYs) in 2018, with the most pronounced decrease observed in 1-5-year olds (decreasing by 65%, from 2556.9 (95% CI 2509.8 to 2604.7) to 892.3 (95% CI 866.9 to 918.3) per 10 5 PYs). The corresponding decreases for the 6-11- and 12-17-year-olds were 36% (1139.9 (95% CI 1110.6 to 1169.7) to 739.9 (95% CI 720.5 to 759.8)) and 20% (572.3 (95% CI 550.4 to 594.9) to 459.5 (95% CI 442.9 to 476.4)) per 10 5 PYs, respectively. The incidence of preschool wheeze decreased over time and was slightly more pronounced in the 1-3 year-olds than in the 4-year-olds. Prevalence of asthma and preschool wheeze also decreased over time, from 18.0% overall in 2008 to 10.2% in 2018 for asthma. Exacerbation rates increased over time from 1.33 (95% CI 1.31 to 1.35) per 10 PYs in 2008 to 1.81 (95% CI 1.78 to 1.83) per 10 PYs in 2018. Conclusion Paediatric asthma incidence decreased in the UK since 2008, particularly in 1-5-year-olds; this was accompanied by a decline in asthma prevalence. Preschool wheeze incidence also decreased in this age group. However, exacerbation rates have been increasing.
Asthma Epidemiology, Paediatric asthma
1175-1180
Kallis, Constantinos
64f6a65e-1d82-46c0-a63a-41ddc6f03853
Maslova, Ekaterina
79c024e0-5f69-4df1-8221-8ccd1a36fb23
Morgan, Ann D.
36522a51-334e-4822-9808-148342e44025
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
20 November 2023
Kallis, Constantinos
64f6a65e-1d82-46c0-a63a-41ddc6f03853
Maslova, Ekaterina
79c024e0-5f69-4df1-8221-8ccd1a36fb23
Morgan, Ann D.
36522a51-334e-4822-9808-148342e44025
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Kallis, Constantinos, Maslova, Ekaterina and Morgan, Ann D.
,
et al.
(2023)
Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study.
Thorax, 78 (12), .
(doi:10.1136/thorax-2022-219757).
Abstract
Background Asthma-related burden remains poorly characterised in children in the UK. We quantified recent trends in asthma prevalence and burden in a UK population-based cohort (1-17-year-olds). Methods The Clinical Practice Research Datalink Aurum database (2008-2018) was used to assess annual asthma incidence and prevalence in 1-17-year-olds and preschool wheeze in 1-5-year-olds, stratified by sex and age. During the same period, annual asthma exacerbation rates were assessed in those with either a diagnosis of preschool wheeze or asthma. Results Annual asthma incidence rates decreased by 51% from 1403.4 (95% CI 1383.7 to 1423.2) in 2008 to 688.0 (95% CI 676.3 to 699.9) per 10 5 person-years (PYs) in 2018, with the most pronounced decrease observed in 1-5-year olds (decreasing by 65%, from 2556.9 (95% CI 2509.8 to 2604.7) to 892.3 (95% CI 866.9 to 918.3) per 10 5 PYs). The corresponding decreases for the 6-11- and 12-17-year-olds were 36% (1139.9 (95% CI 1110.6 to 1169.7) to 739.9 (95% CI 720.5 to 759.8)) and 20% (572.3 (95% CI 550.4 to 594.9) to 459.5 (95% CI 442.9 to 476.4)) per 10 5 PYs, respectively. The incidence of preschool wheeze decreased over time and was slightly more pronounced in the 1-3 year-olds than in the 4-year-olds. Prevalence of asthma and preschool wheeze also decreased over time, from 18.0% overall in 2008 to 10.2% in 2018 for asthma. Exacerbation rates increased over time from 1.33 (95% CI 1.31 to 1.35) per 10 PYs in 2008 to 1.81 (95% CI 1.78 to 1.83) per 10 PYs in 2018. Conclusion Paediatric asthma incidence decreased in the UK since 2008, particularly in 1-5-year-olds; this was accompanied by a decline in asthma prevalence. Preschool wheeze incidence also decreased in this age group. However, exacerbation rates have been increasing.
Text
1175.full
- Version of Record
More information
Accepted/In Press date: 26 June 2023
e-pub ahead of print date: 31 July 2023
Published date: 20 November 2023
Additional Information:
Funding Information: editorial support was provided by Cactus Life Sciences (part of Cactus Communications, Mumbai, India) in accordance with Good Publication Practice (GPP2022) guidelines ( https://www.ismpp.org/gpp-2022 ) and fully funded by AstraZeneca.
Keywords:
Asthma Epidemiology, Paediatric asthma
Identifiers
Local EPrints ID: 486427
URI: http://eprints.soton.ac.uk/id/eprint/486427
ISSN: 0040-6376
PURE UUID: bc1f1363-4788-4bb4-a44a-85dcea0276a9
Catalogue record
Date deposited: 22 Jan 2024 17:35
Last modified: 18 Mar 2024 03:01
Export record
Altmetrics
Contributors
Author:
Constantinos Kallis
Author:
Ekaterina Maslova
Author:
Ann D. Morgan
Corporate Author: et al.
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
