Central serous chorioretinopathy: epidemiology, genetics and clinical features
Central serous chorioretinopathy: epidemiology, genetics and clinical features
Central serous chorioretinopathy (CSCR) is the fourth most common medical retinal disease. Moderate vision loss occurs in approximately one-third of patients who have the chronic form of the disease. CSCR has a multifactorial etiology, with acquired risk factors and increasing evidence of genetic susceptibility factors. The detection of new gene variants in CSCR and association of these variants with age-related macular degeneration provide insights into possible disease mechanisms. The contribution of multimodal ocular imaging and associated research studies to the modern-day clinical investigation of CSCR has been significant. This review aims to provide an overview of the most significant epidemiological and genetic studies of CSCR, in addition to describing its clinical and multimodal imaging features. The review also provides an update of the latest evidence from studies investigating pathophysiological mechanisms in CSCR and current opinions on multimodal imaging to better classify this complex retinal disease.
Khan, Adnan H.
97374057-d7e7-4849-ac94-c125ba1cc360
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
15 May 2024
Khan, Adnan H.
97374057-d7e7-4849-ac94-c125ba1cc360
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Khan, Adnan H. and Lotery, Andrew J.
(2024)
Central serous chorioretinopathy: epidemiology, genetics and clinical features.
Annual Review of Vision Science, 10.
(doi:10.1146/annurev-vision-102122-102907).
Abstract
Central serous chorioretinopathy (CSCR) is the fourth most common medical retinal disease. Moderate vision loss occurs in approximately one-third of patients who have the chronic form of the disease. CSCR has a multifactorial etiology, with acquired risk factors and increasing evidence of genetic susceptibility factors. The detection of new gene variants in CSCR and association of these variants with age-related macular degeneration provide insights into possible disease mechanisms. The contribution of multimodal ocular imaging and associated research studies to the modern-day clinical investigation of CSCR has been significant. This review aims to provide an overview of the most significant epidemiological and genetic studies of CSCR, in addition to describing its clinical and multimodal imaging features. The review also provides an update of the latest evidence from studies investigating pathophysiological mechanisms in CSCR and current opinions on multimodal imaging to better classify this complex retinal disease.
Text
FINAL REVISED Annu Rev Vis Sci- CSCR (2 files merged)
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Accepted/In Press date: 26 January 2024
e-pub ahead of print date: 15 May 2024
Published date: 15 May 2024
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Local EPrints ID: 486683
URI: http://eprints.soton.ac.uk/id/eprint/486683
ISSN: 2374-4650
PURE UUID: 4f4e563a-abd5-445d-8487-fb0f5a45b073
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Date deposited: 01 Feb 2024 17:41
Last modified: 07 Jun 2024 01:56
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