Dysregulated bidirectional epithelial-mesenchymal crosstalk: a core determinant of lung fibrosis progression
Dysregulated bidirectional epithelial-mesenchymal crosstalk: a core determinant of lung fibrosis progression
Progressive lung fibrosis is characterized by dysregulated extracellular matrix (ECM) homeostasis. Understanding of disease pathogenesis remains limited and has prevented the development of effective treatments. While an abnormal wound-healing response is strongly implicated in lung fibrosis initiation, factors that determine why fibrosis progresses rather than regular tissue repair occur are not fully explained. Within human lung fibrosis, there is evidence of altered epithelial and mesenchymal populations as well as cells undergoing epithelial–mesenchymal transition (EMT), a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell–cell adhesion to gain migratory properties. This review will focus on the role of EMT and dysregulated epithelial–mesenchymal crosstalk in progressive lung fibrosis.
Crosstalk, Epithelial–mesenchymal transition (EMT), Lung fibrosis
27-33
Yao, Liudi
3c9ce766-5334-49f7-9517-c4dc2013f933
Xu, Zijian
052c41eb-6256-4ed8-94a4-ab0dfe0f87b1
Davies, Donna E.
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Jones, Mark G.
a6fd492e-058e-4e84-a486-34c6035429c1
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
March 2024
Yao, Liudi
3c9ce766-5334-49f7-9517-c4dc2013f933
Xu, Zijian
052c41eb-6256-4ed8-94a4-ab0dfe0f87b1
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Jones, Mark G.
a6fd492e-058e-4e84-a486-34c6035429c1
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Yao, Liudi, Xu, Zijian, Davies, Donna E., Jones, Mark G. and Wang, Yihua
(2024)
Dysregulated bidirectional epithelial-mesenchymal crosstalk: a core determinant of lung fibrosis progression.
Chinese Medical Journal Pulmonary and Critical Care Medicine, 2 (1), .
(doi:10.1016/j.pccm.2024.02.001).
Abstract
Progressive lung fibrosis is characterized by dysregulated extracellular matrix (ECM) homeostasis. Understanding of disease pathogenesis remains limited and has prevented the development of effective treatments. While an abnormal wound-healing response is strongly implicated in lung fibrosis initiation, factors that determine why fibrosis progresses rather than regular tissue repair occur are not fully explained. Within human lung fibrosis, there is evidence of altered epithelial and mesenchymal populations as well as cells undergoing epithelial–mesenchymal transition (EMT), a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell–cell adhesion to gain migratory properties. This review will focus on the role of EMT and dysregulated epithelial–mesenchymal crosstalk in progressive lung fibrosis.
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EMT in IPF_Review_R1_final
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1-s2.0-S2772558824000021-main
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More information
Accepted/In Press date: 4 February 2024
e-pub ahead of print date: 4 March 2024
Published date: March 2024
Additional Information:
Publisher Copyright:
© 2024 The Author(s)
Keywords:
Crosstalk, Epithelial–mesenchymal transition (EMT), Lung fibrosis
Identifiers
Local EPrints ID: 486788
URI: http://eprints.soton.ac.uk/id/eprint/486788
ISSN: 2097-1982
PURE UUID: 5827f4c8-ffb6-424d-a3b2-9be60a19cf97
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Date deposited: 06 Feb 2024 17:38
Last modified: 27 Apr 2024 01:53
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Author:
Liudi Yao
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