Mechanochemical Cu(II) complexes and propargylamine synthetic adventures
Mechanochemical Cu(II) complexes and propargylamine synthetic adventures
We synthesized and characterized known and new Cu(ii)-salen complexes and investigated their efficacy in yielding propargylamines (PAs) via an A3 coupling reaction mechanochemically. Although the method appears simple, we explicitly describe synthetic obstacles that urge unavoidable solvent use to isolate the molecular entities in high purity. The recovered complexes retain structure and catalytic efficacy, and a library of twenty-four known and unknown PAs are isolated in very good to excellent yields. The scope and limitations of this method are presented.
528-535
Al Jomeh, Ghadah Abdullah S.
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McGown, Andrew
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Richards, Emma
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Tizzard, Graham J.
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Coles, Simon J.
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González-Méndez, Ramón
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Dadswell, Chris
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Spencer, John
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Kostakis, George E.
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9 January 2024
Al Jomeh, Ghadah Abdullah S.
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McGown, Andrew
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Richards, Emma
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Tizzard, Graham J.
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Coles, Simon J.
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González-Méndez, Ramón
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Dadswell, Chris
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Spencer, John
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Kostakis, George E.
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Al Jomeh, Ghadah Abdullah S., McGown, Andrew, Richards, Emma, Tizzard, Graham J., Coles, Simon J., González-Méndez, Ramón, Dadswell, Chris, Spencer, John and Kostakis, George E.
(2024)
Mechanochemical Cu(II) complexes and propargylamine synthetic adventures.
RSC Sustainability, 2 (2), .
(doi:10.1039/d3su00315a).
Abstract
We synthesized and characterized known and new Cu(ii)-salen complexes and investigated their efficacy in yielding propargylamines (PAs) via an A3 coupling reaction mechanochemically. Although the method appears simple, we explicitly describe synthetic obstacles that urge unavoidable solvent use to isolate the molecular entities in high purity. The recovered complexes retain structure and catalytic efficacy, and a library of twenty-four known and unknown PAs are isolated in very good to excellent yields. The scope and limitations of this method are presented.
Text
d3su00315a
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Submitted date: 7 September 2023
Accepted/In Press date: 8 January 2024
e-pub ahead of print date: 9 January 2024
Published date: 9 January 2024
Additional Information:
Funding Information: GAJ thanks Imam Muhammed Ibn Saud University for offering financial support for a PhD fellowship. GEK thanks the EPSRC UK National Crystallography Service at the University of Southampton for collecting the crystallographic data.49 GEK/ER acknowledge financial support from RSC Research Enablement Grant (E22-9127990267). AM, GEK, JS are grateful to the University of Sussex for HEIF Business Collaboration & Commercialisation 2023 funding. We thank Prof. Louise C. Serpell and Dr Youssra Al-Hilaly (Sussex Neuroscience) for accessing the Circular Dichroism apparatus. We acknowledge REACH Separations Ltd in Biocity Nottingham for chirality determination of the products.
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Local EPrints ID: 486844
URI: http://eprints.soton.ac.uk/id/eprint/486844
PURE UUID: 4cec79f5-678a-4d46-975a-1b73f284877e
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Date deposited: 06 Feb 2024 18:40
Last modified: 13 Apr 2024 01:37
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Contributors
Author:
Ghadah Abdullah S. Al Jomeh
Author:
Andrew McGown
Author:
Emma Richards
Author:
Ramón González-Méndez
Author:
Chris Dadswell
Author:
John Spencer
Author:
George E. Kostakis
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