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Mapping domains of early-life determinants of future multimorbidity across three UK longitudinal cohort studies

Mapping domains of early-life determinants of future multimorbidity across three UK longitudinal cohort studies
Mapping domains of early-life determinants of future multimorbidity across three UK longitudinal cohort studies
Many studies use a reductionist approach to isolate the influence of one factor in childhood on multimorbidity rather than consider the combined effect of wider determinants. We explored how potential multiple early-life determinants of multimorbidity can be characterised across three UK cohort studies.

We used the National Child Development Study (NCDS), the 1970 British Cohort Study (BCS70), and the Aberdeen Children of the 1950s Study (ACONF) to identified early-life variables that fit into 12 domains of early-life determinants of multimorbidity. Variables were assigned into 12 domains; principal component analysis reduced the dimensionality of the data and structured variables into subgroups.

The data audit identified 7 domains in ACONF, 10 domains in NCDS and 12 domains in BCS70. Components included maternal fertility histories within the prenatal, antenatal and birth domain, long-term illnesses within the child health domain, educational ability within the child education and health literacy domain, ethnicity within the demography domain, parental health behaviours within the transgenerational domain, housing within the socioeconomic domain and parental-child interactions within the parental-family domain.

Conceptualising the risk of future multimorbidity as lifecourse domains composed of multiple factors can help challenge the existing understanding of disease aetiology and develop new ideas for prevention of multimorbidity.
Stannard, Seb
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Berrington, Ann
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Fraser, Simon
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Paranjothy, Shantini
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Hoyle, Rebecca
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Owen, Rhiannon
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Akbari, Ashley
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Shiranirad, Mozhdeh
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Chiovoloni, Roberta
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Alwan, Nisreen A.
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Stannard, Seb
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Berrington, Ann
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Fraser, Simon
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Paranjothy, Shantini
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Hoyle, Rebecca
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Owen, Rhiannon
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Akbari, Ashley
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Shiranirad, Mozhdeh
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Chiovoloni, Roberta
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Alwan, Nisreen A.
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Stannard, Seb, Berrington, Ann, Fraser, Simon, Paranjothy, Shantini, Hoyle, Rebecca, Owen, Rhiannon, Akbari, Ashley, Shiranirad, Mozhdeh, Chiovoloni, Roberta and Alwan, Nisreen A. (2024) Mapping domains of early-life determinants of future multimorbidity across three UK longitudinal cohort studies (medRxiv) 17pp. (doi:10.1101/2024.02.01.24301771).

Record type: Monograph (Working Paper)

Abstract

Many studies use a reductionist approach to isolate the influence of one factor in childhood on multimorbidity rather than consider the combined effect of wider determinants. We explored how potential multiple early-life determinants of multimorbidity can be characterised across three UK cohort studies.

We used the National Child Development Study (NCDS), the 1970 British Cohort Study (BCS70), and the Aberdeen Children of the 1950s Study (ACONF) to identified early-life variables that fit into 12 domains of early-life determinants of multimorbidity. Variables were assigned into 12 domains; principal component analysis reduced the dimensionality of the data and structured variables into subgroups.

The data audit identified 7 domains in ACONF, 10 domains in NCDS and 12 domains in BCS70. Components included maternal fertility histories within the prenatal, antenatal and birth domain, long-term illnesses within the child health domain, educational ability within the child education and health literacy domain, ethnicity within the demography domain, parental health behaviours within the transgenerational domain, housing within the socioeconomic domain and parental-child interactions within the parental-family domain.

Conceptualising the risk of future multimorbidity as lifecourse domains composed of multiple factors can help challenge the existing understanding of disease aetiology and develop new ideas for prevention of multimorbidity.

Text
2024.02.01.24301771v1.full - Author's Original
Available under License Creative Commons Attribution.
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Published date: 3 February 2024

Identifiers

Local EPrints ID: 486854
URI: http://eprints.soton.ac.uk/id/eprint/486854
PURE UUID: 41ec15e4-556a-4d44-a8b8-dee006840f63
ORCID for Seb Stannard: ORCID iD orcid.org/0000-0002-6139-1020
ORCID for Ann Berrington: ORCID iD orcid.org/0000-0002-1683-6668
ORCID for Simon Fraser: ORCID iD orcid.org/0000-0002-4172-4406
ORCID for Rebecca Hoyle: ORCID iD orcid.org/0000-0002-1645-1071
ORCID for Mozhdeh Shiranirad: ORCID iD orcid.org/0000-0003-4346-3059
ORCID for Nisreen A. Alwan: ORCID iD orcid.org/0000-0002-4134-8463

Catalogue record

Date deposited: 07 Feb 2024 17:33
Last modified: 11 Jun 2024 02:05

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Contributors

Author: Seb Stannard ORCID iD
Author: Ann Berrington ORCID iD
Author: Simon Fraser ORCID iD
Author: Shantini Paranjothy
Author: Rebecca Hoyle ORCID iD
Author: Rhiannon Owen
Author: Ashley Akbari
Author: Mozhdeh Shiranirad ORCID iD
Author: Roberta Chiovoloni

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