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Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up

Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up
Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up

Group-sequential tests may be applied to trials in which the number of patients is fixed, a response variable is measured for each patient at successive follow-up visits, and the accumulated responses are compared across treatment groups. The standard theory is inapplicable because the increments in the accumulated responses are no longer independent. An adjustment can be made to allow for the ratio of between-patient to within-patient variance and for possible first-order autocorrelation. The method is illustrated by reference to a dental trial.

0006-341X
353-359
Armitage, Peter
0e21c8c4-2139-49a4-a631-07ef01298aee
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Worthington, Helen V.
cd95c023-8715-4085-ac5a-189f01778b3d
Armitage, Peter
0e21c8c4-2139-49a4-a631-07ef01298aee
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Worthington, Helen V.
cd95c023-8715-4085-ac5a-189f01778b3d

Armitage, Peter, Stratton, Irene M. and Worthington, Helen V. (1985) Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up. Biometrics, 41 (2), 353-359. (doi:10.2307/2530861).

Record type: Article

Abstract

Group-sequential tests may be applied to trials in which the number of patients is fixed, a response variable is measured for each patient at successive follow-up visits, and the accumulated responses are compared across treatment groups. The standard theory is inapplicable because the increments in the accumulated responses are no longer independent. An adjustment can be made to allow for the ratio of between-patient to within-patient variance and for possible first-order autocorrelation. The method is illustrated by reference to a dental trial.

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Published date: June 1985

Identifiers

Local EPrints ID: 486878
URI: http://eprints.soton.ac.uk/id/eprint/486878
ISSN: 0006-341X
PURE UUID: 5e781a33-4db0-426b-b83c-e2fbb341314f
ORCID for Irene M. Stratton: ORCID iD orcid.org/0000-0003-1172-7865

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Date deposited: 08 Feb 2024 17:31
Last modified: 06 Jun 2024 02:10

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Contributors

Author: Peter Armitage
Author: Irene M. Stratton ORCID iD
Author: Helen V. Worthington

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