Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up
Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up
Group-sequential tests may be applied to trials in which the number of patients is fixed, a response variable is measured for each patient at successive follow-up visits, and the accumulated responses are compared across treatment groups. The standard theory is inapplicable because the increments in the accumulated responses are no longer independent. An adjustment can be made to allow for the ratio of between-patient to within-patient variance and for possible first-order autocorrelation. The method is illustrated by reference to a dental trial.
353-359
Armitage, Peter
0e21c8c4-2139-49a4-a631-07ef01298aee
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Worthington, Helen V.
cd95c023-8715-4085-ac5a-189f01778b3d
June 1985
Armitage, Peter
0e21c8c4-2139-49a4-a631-07ef01298aee
Stratton, Irene M.
772f25b9-23c0-4240-a3f6-1e76b03b172f
Worthington, Helen V.
cd95c023-8715-4085-ac5a-189f01778b3d
Armitage, Peter, Stratton, Irene M. and Worthington, Helen V.
(1985)
Repeated significance tests for clinical trials with a fixed number of patients and variable follow-up.
Biometrics, 41 (2), .
(doi:10.2307/2530861).
Abstract
Group-sequential tests may be applied to trials in which the number of patients is fixed, a response variable is measured for each patient at successive follow-up visits, and the accumulated responses are compared across treatment groups. The standard theory is inapplicable because the increments in the accumulated responses are no longer independent. An adjustment can be made to allow for the ratio of between-patient to within-patient variance and for possible first-order autocorrelation. The method is illustrated by reference to a dental trial.
This record has no associated files available for download.
More information
Published date: June 1985
Identifiers
Local EPrints ID: 486878
URI: http://eprints.soton.ac.uk/id/eprint/486878
ISSN: 0006-341X
PURE UUID: 5e781a33-4db0-426b-b83c-e2fbb341314f
Catalogue record
Date deposited: 08 Feb 2024 17:31
Last modified: 18 Mar 2024 04:01
Export record
Altmetrics
Contributors
Author:
Peter Armitage
Author:
Irene M. Stratton
Author:
Helen V. Worthington
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics